node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GcvT | Smed_3311 | Smed_1184 | Smed_3311 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | 0.925 |
GcvT | Smed_3316 | Smed_1184 | Smed_3316 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc04148 putative aminomethyltransferase protein; Belongs to the GcvT family. | 0.918 |
GcvT | fhs | Smed_1184 | Smed_2298 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.921 |
GcvT | fmt | Smed_1184 | Smed_0055 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
GcvT | folD2 | Smed_1184 | Smed_2095 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.931 |
GcvT | glyA | Smed_1184 | Smed_0816 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
GcvT | glyA-2 | Smed_1184 | Smed_2096 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
GcvT | purH | Smed_1184 | Smed_3189 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: sme:SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.922 |
GcvT | purN | Smed_1184 | Smed_0791 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
GcvT | purU | Smed_1184 | Smed_2094 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.904 |
Smed_3311 | GcvT | Smed_3311 | Smed_1184 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). | 0.925 |
Smed_3311 | Smed_3316 | Smed_3311 | Smed_3316 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc04148 putative aminomethyltransferase protein; Belongs to the GcvT family. | 0.925 |
Smed_3311 | fhs | Smed_3311 | Smed_2298 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.921 |
Smed_3311 | fmt | Smed_3311 | Smed_0055 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
Smed_3311 | folD2 | Smed_3311 | Smed_2095 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.931 |
Smed_3311 | glyA | Smed_3311 | Smed_0816 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
Smed_3311 | glyA-2 | Smed_3311 | Smed_2096 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
Smed_3311 | purH | Smed_3311 | Smed_3189 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: sme:SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.922 |
Smed_3311 | purN | Smed_3311 | Smed_0791 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
Smed_3311 | purU | Smed_3311 | Smed_2094 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.904 |