node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smed_1492 | fhs | Smed_1492 | Smed_2298 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.550 |
Smed_1492 | glyA | Smed_1492 | Smed_0816 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.756 |
Smed_1492 | glyA-2 | Smed_1492 | Smed_2096 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.756 |
Smed_1492 | guaB | Smed_1492 | Smed_0379 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.869 |
Smed_1492 | purA | Smed_1492 | Smed_2616 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.996 |
Smed_1492 | purD | Smed_1492 | Smed_0471 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; KEGG: sme:SMc00993 probable phosphoribosylamine--glycine ligase protein; Belongs to the GARS family. | 0.931 |
Smed_1492 | purE | Smed_1492 | Smed_2672 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.926 |
Smed_1492 | purF | Smed_1492 | Smed_0727 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.953 |
Smed_1492 | purH | Smed_1492 | Smed_3189 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: sme:SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.992 |
Smed_1492 | purN | Smed_1492 | Smed_0791 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.908 |
fhs | Smed_1492 | Smed_2298 | Smed_1492 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.550 |
fhs | glyA | Smed_2298 | Smed_0816 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
fhs | glyA-2 | Smed_2298 | Smed_2096 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
fhs | purD | Smed_2298 | Smed_0471 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; KEGG: sme:SMc00993 probable phosphoribosylamine--glycine ligase protein; Belongs to the GARS family. | 0.673 |
fhs | purE | Smed_2298 | Smed_2672 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.666 |
fhs | purF | Smed_2298 | Smed_0727 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.780 |
fhs | purH | Smed_2298 | Smed_3189 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: sme:SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.986 |
fhs | purN | Smed_2298 | Smed_0791 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
glyA | Smed_1492 | Smed_0816 | Smed_1492 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.756 |
glyA | fhs | Smed_0816 | Smed_2298 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |