node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GltA | Smed_0029 | Smed_1144 | Smed_0029 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | 0.976 |
GltA | Smed_0308 | Smed_1144 | Smed_0308 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: sme:SMc00768 isocitrate lyase. | 0.524 |
GltA | Smed_1558 | Smed_1144 | Smed_1558 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc00169 NAD-malic enzyme oxidoreductase protein. | 0.976 |
GltA | Smed_2522 | Smed_1144 | Smed_2522 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | PFAM: AMP-dependent synthetase and ligase; KEGG: sme:SMc00741 putative fatty-acid-CoA ligase protein. | 0.966 |
GltA | acsA | Smed_1144 | Smed_3194 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.966 |
GltA | fumC | Smed_1144 | Smed_1576 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.965 |
GltA | glcB | Smed_1144 | Smed_3270 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.971 |
GltA | mdh | Smed_1144 | Smed_2944 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.991 |
GltA | sucD | Smed_1144 | Smed_2942 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.805 |
Smed_0029 | GltA | Smed_0029 | Smed_1144 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | 0.976 |
Smed_0029 | Smed_0308 | Smed_0029 | Smed_0308 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: sme:SMc00768 isocitrate lyase. | 0.811 |
Smed_0029 | Smed_0396 | Smed_0029 | Smed_0396 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: sme:SMc00926 probable glycolate oxidase iron-sulfur subunit protein. | 0.464 |
Smed_0029 | Smed_1558 | Smed_0029 | Smed_1558 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc00169 NAD-malic enzyme oxidoreductase protein. | 0.950 |
Smed_0029 | Smed_2522 | Smed_0029 | Smed_2522 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | PFAM: AMP-dependent synthetase and ligase; KEGG: sme:SMc00741 putative fatty-acid-CoA ligase protein. | 0.546 |
Smed_0029 | acsA | Smed_0029 | Smed_3194 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.546 |
Smed_0029 | fumC | Smed_0029 | Smed_1576 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.986 |
Smed_0029 | glcB | Smed_0029 | Smed_3270 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.980 |
Smed_0029 | mdh | Smed_0029 | Smed_2944 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.971 |
Smed_0029 | sucD | Smed_0029 | Smed_2942 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.564 |
Smed_0308 | GltA | Smed_0308 | Smed_1144 | TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: sme:SMc00768 isocitrate lyase. | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. | 0.524 |