STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDIG_72890DNA repair protein Rad1, putative. (391 aa)    
Predicted Functional Partners:
PDIG_10910
3'-5' exonuclease domain-containing protein.
   
 0.991
PDIG_49210
Cell cycle checkpoint protein Rad17, putative.
   
 0.989
PDIG_45270
Checkpoint protein; Belongs to the HUS1 family.
    
 0.976
PDIG_29740
DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.
    
 0.976
PDIG_20300
Protein transport membrane glycoprotein Sec20, putative.
   
 0.973
PDIG_52530
AAA domain-containing protein.
   
 0.941
PDIG_46770
DNA replication factor C subunit Rfc4, putative.
   
 0.922
PDIG_83850
DNA replication factor C subunit Rfc5, putative.
   
 0.909
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.878
PDIG_47360
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.866
Your Current Organism:
Penicillium digitatum
NCBI taxonomy Id: 1170229
Other names: P. digitatum PHI26, Penicillium digitatum PHI26
Server load: low (32%) [HD]