STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cprANADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (696 aa)    
Predicted Functional Partners:
PDIG_72040
Flavodoxin-like domain-containing protein.
 
0.949
PDIG_79740
Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
    
 0.937
DRE2
Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...]
    
 0.841
PDIG_34150
2Fe-2S ferredoxin-type domain-containing protein.
   
 0.825
PDIG_04380
3'-phosphoadenosine-5'-phosphosulfate reductase Met16, putative.
  
 
 0.774
PDIG_15430
Adenylyl-sulfate kinase.
  
 
 0.762
PDIG_74240
Putative oxidoreductase.
    
 0.761
PDIG_35400
Heat shock protein 90.
    
 0.761
PDIG_55470
Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.747
PDIG_57930
Bifunctional P450:NADPH-P450 reductase.
 
  
 0.745
Your Current Organism:
Penicillium digitatum
NCBI taxonomy Id: 1170229
Other names: P. digitatum PHI26, Penicillium digitatum PHI26
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.