node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abu_0284 | dnaX | Abu_0284 | Abu_0285 | Conserved hypothetical protein, putative DSBA oxidoreductase; Pfam match to PF01323 DSBA, score 9.9, E-value 1.5E-005. | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.599 |
Abu_0284 | hemC | Abu_0284 | Abu_0283 | Conserved hypothetical protein, putative DSBA oxidoreductase; Pfam match to PF01323 DSBA, score 9.9, E-value 1.5E-005. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.772 |
Abu_0284 | murI | Abu_0284 | Abu_0286 | Conserved hypothetical protein, putative DSBA oxidoreductase; Pfam match to PF01323 DSBA, score 9.9, E-value 1.5E-005. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.679 |
Abu_0586 | murI | Abu_0586 | Abu_0286 | HAM1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.910 |
ddlA | murD | Abu_0745 | Abu_1898 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Pfam match to PF08245 Mur_ligase_M, score 116.4, E-value 8.5E-033; Belongs to the MurCDEF family. | 0.946 |
ddlA | murG | Abu_0745 | Abu_1909 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.956 |
ddlA | murI | Abu_0745 | Abu_0286 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.546 |
dnaX | Abu_0284 | Abu_0285 | Abu_0284 | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | Conserved hypothetical protein, putative DSBA oxidoreductase; Pfam match to PF01323 DSBA, score 9.9, E-value 1.5E-005. | 0.599 |
dnaX | hemC | Abu_0285 | Abu_0283 | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.592 |
dnaX | murI | Abu_0285 | Abu_0286 | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.814 |
glsA | gltB | Abu_2331 | Abu_1827 | Pfam match to PF04960 Glutaminase, score 515.8, E-value 8E-165; Belongs to the glutaminase family. | Glutamate synthase, large chain; Pfam matches to PF01645 Glu_synthase, score 688.8, E-value 3.6E-204, and to PF00310 GATase_2, score 484.4, E-value 1.2E-142, and to PF04898 Glu_syn_central, score 323.9, E-value 2.7E-094, and to PF01493 GXGXG, score 280.5, E-value 2.9E-081. | 0.945 |
glsA | murD | Abu_2331 | Abu_1898 | Pfam match to PF04960 Glutaminase, score 515.8, E-value 8E-165; Belongs to the glutaminase family. | Pfam match to PF08245 Mur_ligase_M, score 116.4, E-value 8.5E-033; Belongs to the MurCDEF family. | 0.901 |
glsA | murI | Abu_2331 | Abu_0286 | Pfam match to PF04960 Glutaminase, score 515.8, E-value 8E-165; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.920 |
glsA | purQ | Abu_2331 | Abu_2123 | Pfam match to PF04960 Glutaminase, score 515.8, E-value 8E-165; Belongs to the glutaminase family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
gltB | glsA | Abu_1827 | Abu_2331 | Glutamate synthase, large chain; Pfam matches to PF01645 Glu_synthase, score 688.8, E-value 3.6E-204, and to PF00310 GATase_2, score 484.4, E-value 1.2E-142, and to PF04898 Glu_syn_central, score 323.9, E-value 2.7E-094, and to PF01493 GXGXG, score 280.5, E-value 2.9E-081. | Pfam match to PF04960 Glutaminase, score 515.8, E-value 8E-165; Belongs to the glutaminase family. | 0.945 |
gltB | murD | Abu_1827 | Abu_1898 | Glutamate synthase, large chain; Pfam matches to PF01645 Glu_synthase, score 688.8, E-value 3.6E-204, and to PF00310 GATase_2, score 484.4, E-value 1.2E-142, and to PF04898 Glu_syn_central, score 323.9, E-value 2.7E-094, and to PF01493 GXGXG, score 280.5, E-value 2.9E-081. | Pfam match to PF08245 Mur_ligase_M, score 116.4, E-value 8.5E-033; Belongs to the MurCDEF family. | 0.504 |
gltB | murI | Abu_1827 | Abu_0286 | Glutamate synthase, large chain; Pfam matches to PF01645 Glu_synthase, score 688.8, E-value 3.6E-204, and to PF00310 GATase_2, score 484.4, E-value 1.2E-142, and to PF04898 Glu_syn_central, score 323.9, E-value 2.7E-094, and to PF01493 GXGXG, score 280.5, E-value 2.9E-081. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.579 |
gltB | purQ | Abu_1827 | Abu_2123 | Glutamate synthase, large chain; Pfam matches to PF01645 Glu_synthase, score 688.8, E-value 3.6E-204, and to PF00310 GATase_2, score 484.4, E-value 1.2E-142, and to PF04898 Glu_syn_central, score 323.9, E-value 2.7E-094, and to PF01493 GXGXG, score 280.5, E-value 2.9E-081. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
hemC | Abu_0284 | Abu_0283 | Abu_0284 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Conserved hypothetical protein, putative DSBA oxidoreductase; Pfam match to PF01323 DSBA, score 9.9, E-value 1.5E-005. | 0.772 |
hemC | dnaX | Abu_0283 | Abu_0285 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.592 |