node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Abu_0473 | Abu_0977 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | 0.978 |
hisA | hisD | Abu_0473 | Abu_0384 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.979 |
hisA | hisF1 | Abu_0473 | Abu_0054 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.989 |
hisA | hisF2 | Abu_0473 | Abu_0672 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.985 |
hisA | hisF3 | Abu_0473 | Abu_0690 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.984 |
hisA | hisG | Abu_0473 | Abu_0322 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.968 |
hisA | hisH1 | Abu_0473 | Abu_0475 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.997 |
hisA | hisH2 | Abu_0473 | Abu_0671 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.987 |
hisA | hisH3 | Abu_0473 | Abu_0689 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.985 |
hisA | hisI | Abu_0473 | Abu_0121 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | Bifunctional phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase; Pfam matches to PF01502 PRA-CH, score 173.5, E-value 4.8E-049, and to PF01503 PRA-PH, score 98.2, E-value 2.2E-026; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | hisA | Abu_0977 | Abu_0473 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977 His_biosynth, score 351.6, E-value 1.2E-102. | 0.978 |
hisB | hisD | Abu_0977 | Abu_0384 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisF1 | Abu_0977 | Abu_0054 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.994 |
hisB | hisF2 | Abu_0977 | Abu_0672 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.993 |
hisB | hisF3 | Abu_0977 | Abu_0690 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.992 |
hisB | hisG | Abu_0977 | Abu_0322 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.977 |
hisB | hisH1 | Abu_0977 | Abu_0475 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.993 |
hisB | hisH2 | Abu_0977 | Abu_0671 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.992 |
hisB | hisH3 | Abu_0977 | Abu_0689 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.992 |
hisB | hisI | Abu_0977 | Abu_0121 | Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475 IGPD, score 259.8, E-value 5.1E-075. | Bifunctional phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase; Pfam matches to PF01502 PRA-CH, score 173.5, E-value 4.8E-049, and to PF01503 PRA-PH, score 98.2, E-value 2.2E-026; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |