STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaKDnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (628 aa)    
Predicted Functional Partners:
dnaJ
Co-chaperone and heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactio [...]
 0.999
htpG
Heat shock protein 90 HtpG; Molecular chaperone. Has ATPase activity.
  
 0.997
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
 
 0.997
groEL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.990
cbpA
Curved DNA-binding protein CbpA; Pfam matches to PF00226 DnaJ, score 127.4, E-value 3.1E-037, and to PF01556 DnaJ_C, score 67.4, E-value 4.1E-017.
 0.981
clpB
ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724 AAA_2, score 376.3, E-value 4.4E-110, and to PF00004 AAA, score 85.3, E-value 1.3E-025, and to PF02861 Clp_N, score 41.6, E-value 2.4E-009; Belongs to the ClpA/ClpB family.
  
 
 0.967
clpA
ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724 AAA_2, score 284, E-value 2.6E-082, and to PF00004 AAA, score 52.3, E-value 1.3E-015, and to PF02861 Clp_N, score 32.2, E-value 1.6E-006; Belongs to the ClpA/ClpB family.
  
 
 0.965
hrcA
Putative heat shock regulator.
  
  
 0.957
iscU
NifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 
 0.953
groES
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.943
Your Current Organism:
Arcobacter butzleri
NCBI taxonomy Id: 367737
Other names: A. butzleri RM4018, Arcobacter butzleri RM4018, Arcobacter butzleri str. RM4018, Arcobacter butzleri strain RM4018
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