node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abu_0661 | glmU | Abu_0661 | Abu_2204 | UDP-hexose dehydrogenase; Pfam matches to PF03721 UDPG_MGDP_dh_N, score 239.8, E-value 5.3E-069, and to PF00984 UDPG_MGDP_dh, score 149.4, E-value 8.5E-042, and to PF03720 UDPG_MGDP_dh_C, score 98.5, E-value 1.9E-026; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | Bifunctional UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.914 |
Abu_0661 | lpxA | Abu_0661 | Abu_2215 | UDP-hexose dehydrogenase; Pfam matches to PF03721 UDPG_MGDP_dh_N, score 239.8, E-value 5.3E-069, and to PF00984 UDPG_MGDP_dh, score 149.4, E-value 8.5E-042, and to PF03720 UDPG_MGDP_dh_C, score 98.5, E-value 1.9E-026; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.821 |
Abu_0661 | murA | Abu_0661 | Abu_1843 | UDP-hexose dehydrogenase; Pfam matches to PF03721 UDPG_MGDP_dh_N, score 239.8, E-value 5.3E-069, and to PF00984 UDPG_MGDP_dh, score 149.4, E-value 8.5E-042, and to PF03720 UDPG_MGDP_dh_C, score 98.5, E-value 1.9E-026; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.905 |
fabZ | lpxA | Abu_2216 | Abu_2215 | 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.979 |
fabZ | lpxB | Abu_2216 | Abu_2217 | 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.769 |
fabZ | lpxC | Abu_2216 | Abu_2039 | 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.934 |
fabZ | lpxD | Abu_2216 | Abu_1158 | 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.731 |
glmU | Abu_0661 | Abu_2204 | Abu_0661 | Bifunctional UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-hexose dehydrogenase; Pfam matches to PF03721 UDPG_MGDP_dh_N, score 239.8, E-value 5.3E-069, and to PF00984 UDPG_MGDP_dh, score 149.4, E-value 8.5E-042, and to PF03720 UDPG_MGDP_dh_C, score 98.5, E-value 1.9E-026; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | 0.914 |
glmU | lpxA | Abu_2204 | Abu_2215 | Bifunctional UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.841 |
glmU | murA | Abu_2204 | Abu_1843 | Bifunctional UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.941 |
kdsB | kdtA | Abu_1272 | Abu_1976 | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.984 |
kdsB | lpxA | Abu_1272 | Abu_2215 | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.812 |
kdsB | lpxB | Abu_1272 | Abu_2217 | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.823 |
kdsB | lpxC | Abu_1272 | Abu_2039 | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.809 |
kdsB | lpxD | Abu_1272 | Abu_1158 | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.820 |
kdsB | lpxK | Abu_1272 | Abu_1248 | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | Lipid A biosynthesis protein LpxK; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.837 |
kdtA | kdsB | Abu_1976 | Abu_1272 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 3-deoxy-manno-octulosonate cytidylyltransferase; Pfam match to PF02348 CTP_transf_3, score 183.9, E-value 3.5E-052; Belongs to the KdsB family. | 0.984 |
kdtA | lpxA | Abu_1976 | Abu_2215 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.840 |
kdtA | lpxB | Abu_1976 | Abu_2217 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.851 |
kdtA | lpxC | Abu_1976 | Abu_2039 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.842 |