STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (282 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.998
bioA
7,8-diaminopelargonic acid synthetase; Pfam match to PF00202 Aminotran_3, score 446.9, E-value 2.4E-131; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.990
bioF
8-amino-7-oxononanoate synthase; Pfam match to PF00155 Aminotran_1_2, score 78.2, E-value 1E-021.
  
 0.962
birA
biotin--acetyl-CoA-carboxylase ligase; Pfam match to PF03099 BPL_LipA_LipB, score 37.6, E-value 1E-009.
  
 
 0.935
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.819
Abu_2236
Conserved hypothetical protein; Pfam match to PF00149 Metallophos, score 45.3, E-value 1.9E-010.
  
    0.804
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
     
 0.552
ubiE
Bifunctional ubiquinone/menaquinone biosynthesis methlytransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  
  
 0.545
Abu_1074
Methyltransferase, putative; Pfam match to PF08241 Methyltransf_11, score 82.1, E-value 1.6E-021.
  
  
 0.545
Abu_1369
Conserved hypothetical protein.
  
    0.542
Your Current Organism:
Arcobacter butzleri
NCBI taxonomy Id: 367737
Other names: A. butzleri RM4018, Arcobacter butzleri RM4018, Arcobacter butzleri str. RM4018, Arcobacter butzleri strain RM4018
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.