STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
degPCOG family: trypsin-like serineproteases_ typically periplasmic_ contain C-terminal PDZdomain; DegP or HtrA; Orthologue of BL0555; PFAM_ID: PDZ; PFAM_ID: trypsin. (641 aa)    
Predicted Functional Partners:
arc
Probable Aaa-family ATPase; COG family: ATPases of the Aaa+ class; Orthologue of BL1794; PFAM_ID:AAA.
    
 0.987
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]
       0.677
BAD_0371
COG family: sensory transduction histidine kinases; Orthologue of BL1646.
  
  
 0.644
rpsF
30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
   
 
 0.613
BAD_0569
COG family: sensory transduction histidine kinases; Orthologue of BL0006; PFAM_ID: HAMP; PFAM_ID: HATPase_c; PFAM_ID: signal.
  
 0.609
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
 
 
   0.609
BAD_0058
Probable cation-transporting ATPase V; COG family: cation transport ATPases; Orthologue of BL0554; PFAM_ID: Hydrolase; PFAM_ID:E1-E2_ATPase.
       0.603
rplK
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
    
   0.594
leuA
Possible TetR-type transcriptional regulator; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
    
  0.588
dnaK
Chaperone protein dnaK (Heat shock protein 70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.587
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.