STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa)    
Predicted Functional Partners:
cysS
cysteinyl-tRNA synthetase; Catalyzes a two-step reaction_charges a cysteineby linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; Orthologue of BL0301; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.825
leuS
leucyl-tRNA synthetase; Charges leucine bylinking carboxyl group to alpha-phosphate of ATP and thentransfers aminoacyl-adenylate to its tRNA; Orthologue of Rv0041_ BL1450; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.765
trpS
COG family:tryptophanyl-tRNA synthetase; COG0180; Orthologue of BL0600; PFAM_ID: tRNA-synt_1b; Tryptophan-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.721
argS
arginyl-tRNA synthetase; Catalyzes a two-step reaction_ first charging anarginine molecule by linking its carboxyl group to thealpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; Orthologue of BL1272.
  
 
 0.707
thrS
threonyl-tRNA synthetase; Catalyzes a two-step reaction_ first charging athreonine molecule by linking its carboxyl group to thealpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; Orthologue of Rv2614c_BL0724; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.698
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
  
 0.698
BAD_0368
Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL1634; PFAM_ID: DAGKc.
       0.689
valS
Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner.
   
  
 0.686
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
   
 
 0.675
pheS
phenylalanyl-tRNA synthetase alpha chain; Catalyzes a two-step reaction_ first charging aphenylalanine molecule by linking its carboxyl group tothe alpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; forms a heterotetramer ofalpha(2)beta(2); binds two magnesium; Orthologue of BL1067; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
  
 
 0.668
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.