STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuSleucyl-tRNA synthetase; Charges leucine bylinking carboxyl group to alpha-phosphate of ATP and thentransfers aminoacyl-adenylate to its tRNA; Orthologue of Rv0041_ BL1450; Belongs to the class-I aminoacyl-tRNA synthetase family. (990 aa)    
Predicted Functional Partners:
pheT
phenylalanyl-tRNA synthetase beta chain; Catalyzes a two-step reaction_ first charging aphenylalanine molecule by linking its carboxyl group tothe alpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; Orthologue of Tfu_2060_BL1066; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.993
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
0.970
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.954
argS
arginyl-tRNA synthetase; Catalyzes a two-step reaction_ first charging anarginine molecule by linking its carboxyl group to thealpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; Orthologue of BL1272.
 
 0.948
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
 0.944
valS
Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner.
   
0.936
lysS
lysyl-tRNA synthetase 1; Catalyzes a two-step reaction_ first charging alysine molecule by linking its carboxyl group to thealpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; Orthologue of BL1654; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 0.907
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
  
 0.850
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
  
 
 0.847
thrS
threonyl-tRNA synthetase; Catalyzes a two-step reaction_ first charging athreonine molecule by linking its carboxyl group to thealpha-phosphate of ATP_ followed by transfer of theaminoacyl-adenylate to its tRNA; Orthologue of Rv2614c_BL0724; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.842
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.