node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAD_0874 | thiD | BAD_0874 | BAD_1146 | Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | 0.976 |
BAD_0874 | thiE | BAD_0874 | BAD_1145 | Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. | Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.633 |
BAD_0874 | thiG | BAD_0874 | BAD_0089 | Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. | Thiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.633 |
BAD_0874 | thiM | BAD_0874 | BAD_1144 | Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.944 |
BAD_1143 | thiM | BAD_1143 | BAD_1144 | Transcriptional regulator; MarR family; Orthologue of ABC2794. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.411 |
BAD_1147 | thiD | BAD_1147 | BAD_1146 | Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL0112; PFAM_ID: DUF77. | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | 0.693 |
BAD_1147 | thiE | BAD_1147 | BAD_1145 | Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL0112; PFAM_ID: DUF77. | Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.437 |
BAD_1147 | thiM | BAD_1147 | BAD_1144 | Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL0112; PFAM_ID: DUF77. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.583 |
folC | folP | BAD_1088 | BAD_0411 | COG family: folylpolyglutamatesynthase; Orthologue of BL1353; PFAM_ID: Mur_ligase. | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
folC | thiM | BAD_1088 | BAD_1144 | COG family: folylpolyglutamatesynthase; Orthologue of BL1353; PFAM_ID: Mur_ligase. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.593 |
folP | folC | BAD_0411 | BAD_1088 | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | COG family: folylpolyglutamatesynthase; Orthologue of BL1353; PFAM_ID: Mur_ligase. | 0.998 |
folP | thiM | BAD_0411 | BAD_1144 | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.491 |
thiD | BAD_0874 | BAD_1146 | BAD_0874 | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. | 0.976 |
thiD | BAD_1147 | BAD_1146 | BAD_1147 | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL0112; PFAM_ID: DUF77. | 0.693 |
thiD | thiE | BAD_1146 | BAD_1145 | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
thiD | thiG | BAD_1146 | BAD_0089 | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | Thiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.796 |
thiD | thiM | BAD_1146 | BAD_1144 | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.994 |
thiE | BAD_0874 | BAD_1145 | BAD_0874 | Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. | 0.633 |
thiE | BAD_1147 | BAD_1145 | BAD_1147 | Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL0112; PFAM_ID: DUF77. | 0.437 |
thiE | thiD | BAD_1145 | BAD_1146 | Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113. | 0.999 |