STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2525 histidinol-phosphate aminotransferase. (352 aa)    
Predicted Functional Partners:
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mhu:Mhun_0920 imidazoleglycerol-phosphate dehydratase.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.996
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis.
  
 0.979
ABN57827.1
TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: mhu:Mhun_2526 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.968
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.967
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.965
ABN57829.1
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
     
 0.964
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.958
ABN57229.1
PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mhu:Mhun_1032 prephenate dehydratase.
 
 
 0.946
ABN55994.1
PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2478 aminotransferase, class I and II.
 
 
 0.940
Your Current Organism:
Methanoculleus marisnigri
NCBI taxonomy Id: 368407
Other names: M. marisnigri JR1, Methanoculleus marisnigri JR1, Methanoculleus marisnigri str. JR1, Methanoculleus marisnigri strain JR1
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