STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mptAGTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (313 aa)    
Predicted Functional Partners:
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
  0.901
ABN56460.1
PFAM: pyruvate kinase; KEGG: mba:Mbar_A0175 pyruvate kinase; Belongs to the pyruvate kinase family.
 
  
  0.845
ABN56240.1
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: mhu:Mhun_2811 ribonucleoside-triphosphate reductase, anaerobic.
  
  
  0.832
ABN56253.1
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: mhu:Mhun_2811 ribonucleoside-triphosphate reductase, anaerobic.
  
  
  0.831
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
  0.804
ABN56866.1
TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: mhu:Mhun_1167 adenylyl cyclase CyaB, putative.
    
  0.803
ABN58256.1
PFAM: NUDIX hydrolase; KEGG: pis:Pisl_0088 NUDIX hydrolase.
    
  0.803
mptE
Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
 
   
 0.673
ABN57619.1
PFAM: transferase hexapeptide repeat containing protein; KEGG: mhu:Mhun_0621 carbonic anhydrase (gamma family Zn(II)-dependent enzymes).
  
  
 0.642
mptD
Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family.
 
   
 0.615
Your Current Organism:
Methanoculleus marisnigri
NCBI taxonomy Id: 368407
Other names: M. marisnigri JR1, Methanoculleus marisnigri JR1, Methanoculleus marisnigri str. JR1, Methanoculleus marisnigri strain JR1
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