node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABN55988.1 | ABN57157.1 | Memar_0053 | Memar_1226 | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | 0.988 |
ABN55988.1 | ABN57389.1 | Memar_0053 | Memar_1460 | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | 0.589 |
ABN55988.1 | thi4 | Memar_0053 | Memar_2251 | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.589 |
ABN55988.1 | thiE | Memar_0053 | Memar_0261 | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.910 |
ABN57157.1 | ABN55988.1 | Memar_1226 | Memar_0053 | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | 0.988 |
ABN57157.1 | ABN57389.1 | Memar_1226 | Memar_1460 | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | 0.993 |
ABN57157.1 | thi4 | Memar_1226 | Memar_2251 | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.890 |
ABN57157.1 | thiC | Memar_1226 | Memar_1558 | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.943 |
ABN57157.1 | thiE | Memar_1226 | Memar_0261 | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
ABN57389.1 | ABN55988.1 | Memar_1460 | Memar_0053 | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | 0.589 |
ABN57389.1 | ABN57157.1 | Memar_1460 | Memar_1226 | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | KEGG: mhu:Mhun_1140 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | 0.993 |
ABN57389.1 | thi4 | Memar_1460 | Memar_2251 | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.561 |
ABN57389.1 | thiC | Memar_1460 | Memar_1558 | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.589 |
ABN57389.1 | thiE | Memar_1460 | Memar_0261 | KEGG: mtp:Mthe_0828 phosphomethylpyrimidine kinase. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.920 |
ABN58170.1 | thi4 | Memar_2247 | Memar_2251 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.902 |
ABN58173.1 | htpX | Memar_2250 | Memar_2252 | KEGG: mhu:Mhun_2871 hypothetical protein. | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; peptidase M56, BlaR1; KEGG: mhu:Mhun_1307 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.498 |
ABN58173.1 | thi4 | Memar_2250 | Memar_2251 | KEGG: mhu:Mhun_2871 hypothetical protein. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.647 |
htpX | ABN58173.1 | Memar_2252 | Memar_2250 | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; peptidase M56, BlaR1; KEGG: mhu:Mhun_1307 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | KEGG: mhu:Mhun_2871 hypothetical protein. | 0.498 |
htpX | thi4 | Memar_2252 | Memar_2251 | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; peptidase M56, BlaR1; KEGG: mhu:Mhun_1307 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.541 |
thi4 | ABN55988.1 | Memar_2251 | Memar_0053 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. | 0.589 |