STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtnPMethylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (262 aa)    
Predicted Functional Partners:
Tpen_0246
Translation initiation factor 2B subunit I family (IF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
  
 
 0.956
speE
Spermine synthase / spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
  
 
 0.939
speE-2
Spermine synthase / spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
  
 
 0.939
Tpen_0060
PFAM: purine and other phosphorylases, family 1; KEGG: sto:ST0975 hypothetical 5'-methylthioadenosine phosphorylase.
    
 0.925
Tpen_0062
PFAM: purine and other phosphorylases, family 1; KEGG: sai:Saci_1247 5'-methylthioadenosine phosphorylase.
    
 0.925
Tpen_0126
PFAM: purine and other phosphorylases, family 1; KEGG: sto:ST0975 hypothetical 5'-methylthioadenosine phosphorylase.
    
 0.925
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
  
 0.797
Tpen_0616
KEGG: sto:ST0515 hypothetical protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM; Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB.
     
 0.687
Tpen_0620
PFAM: phosphoribosyltransferase; KEGG: ape:APE0490 hypothetical protein.
  
  
 0.630
Tpen_0619
TIGRFAM: tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic-like; KEGG: ape:APE1646 tRNA intron endonuclease.
       0.601
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.