STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tpen_0885KEGG: pai:PAE2993 DNA topoisomerase; PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein. (631 aa)    
Predicted Functional Partners:
Tpen_0206
KEGG: tac:Ta1149 hypothetical protein.
  
 0.874
Tpen_0630
PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A related protein.
  
 0.874
Tpen_0877
PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1; KEGG: ape:APE1436 ATP-dependent RNA helicase, eIF-4A family.
    
 0.870
Tpen_1498
KEGG: pai:PAE2544 hypothetical protein.
    
 0.870
Tpen_1573
PFAM: metallophosphoesterase; KEGG: gsu:GSU1421 nuclease SbcCD, D subunit, putative.
  
 0.831
Tpen_0527
PFAM: SMC domain protein; KEGG: pai:PAE2280 hypothetical protein.
 
 0.829
Tpen_0985
PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; SMART: DEAD-like helicases-like; KEGG: pfu:PF0564 ATP-dependent RNA helicase hepa, putative.
 
 
 0.819
Tpen_0638
Hypothetical protein.
  
 0.808
Tpen_0743
PFAM: Rad51-like; SMART: AAA ATPase; KEGG: pai:PAE0654 DNA repair protein radA.
  
 0.808
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
  
 0.808
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.