STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (597 aa)    
Predicted Functional Partners:
LELG_01954
Tr-type G domain-containing protein.
   
 0.997
LELG_03537
TPR_REGION domain-containing protein.
   
 0.997
LELG_04124
WD_REPEATS_REGION domain-containing protein.
    
 0.995
LELG_04121
Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.
    
 0.993
LELG_05647
Uncharacterized protein.
   
 0.987
LELG_01878
Small nuclear ribonucleoprotein Sm D2.
   
 0.979
LELG_04634
Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.
   
 0.965
LELG_02100
Uncharacterized protein.
   
 0.959
LELG_01884
Matrin-type domain-containing protein.
    
 0.955
LELG_05254
Sm domain-containing protein.
   
 0.953
Your Current Organism:
Lodderomyces elongisporus
NCBI taxonomy Id: 379508
Other names: L. elongisporus NRRL YB-4239, Lodderomyces elongisporus NRRL YB-4239
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.