STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFZ91933.1acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)    
Predicted Functional Partners:
SFZ92544.1
3-hydroxyacyl-CoA dehydrogenase.
  
 0.980
SFZ89237.1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.978
SFZ92546.1
acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.947
SFZ94340.1
acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.947
SFZ90770.1
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
  
 0.937
SFZ91935.1
Hypothetical protein.
   
  0.937
SFZ93764.1
Acyl-CoA hydrolase.
  
 0.927
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.924
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.922
SFZ94560.1
3-hydroxybutyryl-CoA dehydrogenase.
  
 
 0.914
Your Current Organism:
Flaviramulus basaltis
NCBI taxonomy Id: 369401
Other names: CIP 109091, DSM 18180, F. basaltis, Flaviramulus basaltis Einen and Ovreas 2006 emend. Zhang et al. 2013, strain H35
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.