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FRO2 protein (Arabidopsis thaliana) - STRING interaction network
"FRO2" - Ferric reduction oxidase 2 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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FRO2Ferric reduction oxidase 2; Flavocytochrome that transfers electrons across the plasma membrane to reduce ferric iron chelates to form soluble ferrous iron in the rhizosphere. May be involved in the delivery of iron to developing pollen grains. Acts also as a copper-chelate reductase. Involved in glycine betaine-mediated chilling tolerance and reactive oxygen species accumulation (725 aa)    
Predicted Functional Partners:
IRT1
Fe(2+) transport protein 1; High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions (347 aa)
     
   
  0.994
NRAMP4
Metal transporter Nramp4; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP3 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP3, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts (512 aa)
     
   
  0.907
NRAMP3
Metal transporter Nramp3; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP4 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP4, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts. Involved in basal resistance to the bacterial pathogen E.chrysanthemi (509 aa)
     
   
  0.906
FRU
FER-like regulator of iron uptake; Transcription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply (318 aa)
           
  0.885
IRT2
Fe(2+) transport protein 2; High-affinity iron transporter that mediates under iron- deficiency the iron uptake from the rhizosphere across the plasma membrane in the root epidermal layer. Could also be capable of transporting zinc ions (350 aa)
     
   
  0.881
FRD3
MATE efflux family protein; Citrate transporter responsible for loading citrate into xylem tissues, which helps facilitate iron transport to shoots (PubMed-12172022, PubMed-15310833, PubMed-17351051, PubMed-18826429). Mediates the citrate release in the apoplastic spaces during plant development allowing iron nutrition between symplastically disconnected tissues (PubMed-21742986) (526 aa)
           
  0.877
bHLH39
Basic helix-loop-helix 39 (258 aa)
     
   
  0.868
NAS1
Nicotianamine synthase 1; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron (320 aa)
           
  0.862
bHLH38
Basic helix-loop-helix 38 (253 aa)
     
   
  0.828
HMA3
Heavy metal atpase 3 (542 aa)
     
   
  0.826
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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