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MC1 protein (Arabidopsis thaliana) - STRING interaction network
"MC1" - Metacaspase 1 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
MC1Metacaspase 1; Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Acts as a positive regulator of cell death. Required for both oxidative stress cell death response and hypersensitive cell death response mediated by immune response (367 aa)    
Predicted Functional Partners:
LSD1
Zinc finger protein LSD1 (210 aa)
     
 
  0.887
SERPIN1
serpin-ZX; Inhibits metacaspase-9 cysteine protease (391 aa)
           
  0.671
DELTA-VPE
Legumain; Asparagine-specific endopeptidase that may be involved in processing of proteins targeted to vacuoles (By similarity). Probably involved in post-translational proteolysis of seed storage proteins in the protein storage vacuole of developing seeds (PubMed-12417707, PubMed-14688293). Exhibits a caspase-1- like activity in extracellular granules. At the early stage of seed development, required for the formation of the seed coat, by regulating cell death of specific cell layers in inner integument (PubMed-15705955) (571 aa)
     
   
  0.648
BIL4
BRZ-INSENSITIVE-LONG HYPOCOTYLS 4 (239 aa)
     
   
  0.584
AT3G03370
Uncharacterized protein (244 aa)
     
   
  0.582
SWI1
SWITCH1; Required for fertility. Involved in chromatid cohesion establishment, in chromosome structure during male and female meiosis (e.g. the synapse formation between homologous chromosomes, the recombination, and the cohesion of both chromatid arm and centromere), and in axial element formation. Regulates the switch from mitosis to the reductional meiosis division of megaspores prior to the female gametogenesis (megasporogenesis) (639 aa)
           
  0.560
AT2G10440
Uncharacterized protein; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) (935 aa)
           
  0.559
ADR1-L2
ADR1-like 2; Probable disease resistance protein (811 aa)
     
   
  0.523
AT4G02690
Bax inhibitor-1 family protein (248 aa)
           
  0.512
AT1G03070
Bax inhibitor-1 family protein (247 aa)
           
  0.512
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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