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TOC33 protein (Arabidopsis thaliana) - STRING interaction network
"TOC33" - Translocon at the outer envelope membrane of chloroplasts 33 in Arabidopsis thaliana
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Known Interactions
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Predicted Interactions
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co-expression
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TOC33Translocon at the outer envelope membrane of chloroplasts 33; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Binds GTP, GDP, XTP, but not ATP. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast, especially during early development stages (297 aa)    
Predicted Functional Partners:
TOC75-III
Component of the translocon outer membrane (TOC) complex. Forms the outer envelope translocation channel (beta-barrel). Plays a role in preprotein conductance. Imported into chloroplast. Expressed in young dividing photosynthetic tissues. Knockout mutants are embryo lethal with arrested development at the two-cell stage. Knockout mutants have abnormal etioplasts (818 aa)
     
   
  0.986
OEP80
Outer envelope protein 80, chloroplastic; AtOEP80 is paralog to the chloroplastic protein translocation channel Toc75. Mutations in this locus result in embryo lethality; Belongs to the OEP80 (TC 1.B.33.2) family (732 aa)
     
   
  0.974
AKR2
Ankyrin repeat domain-containing protein 2A; Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle. Seems to be involved in the regulation of hydrogen peroxide levels during biotic and abiotic stresses by optimizing [...] (350 aa)
     
 
  0.946
TIC110
Translocon at the inner envelope membrane of chloroplasts 110; Involved in protein precursor import into chloroplasts. Forms a voltage-dependent cation-selective channel at the inner envelope of chloroplasts, which specifically responds to a transit peptide. Associates with both the precursor and mature forms of the preprotein (1016 aa)
     
 
  0.928
Tic22-IV
Protein TIC 22, chloroplastic; Involved in protein precursor import into chloroplasts. Imported into the intermembrane space via the Toc translocon. May be involved in the import pathway used by proteins without a cleavable N-terminal pre-sequence (By similarity); Belongs to the Tic22 family (268 aa)
     
   
  0.901
Tic20-I
Translocon at the inner envelope membrane of chloroplasts 20; Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope. Seems to be specific for photosynthesis-related pre-proteins. Partially redundant with TIC20-IV, but not with TIC20-II or TIC20-V (274 aa)
     
   
  0.856
TOC75-IV
Outer membrane OMP85 family protein; Mediates the insertion of proteins targeted to the outer membrane of chloroplasts. Required for the import of protein precursors into chloroplasts. Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane (By similarity). Required for etioplast formation and/or etioplast-chloroplast transition during deetiolation (396 aa)
     
   
  0.851
TIC40
Hydroxyproline-rich glycoprotein family protein; Involved in protein precursor import into chloroplasts. Part of the motor complex consisting of a co-chaperone (TIC40) and a chaperone (HSP93) associated with the import channel (TIC110). Causes the release of bound transit peptides from TIC110 and stimulates ATP hydrolysis by HSP93. Involved in reinsertion of proteins from the chloroplast stroma into the inner membrane (447 aa)
     
   
  0.846
TOC159
Translocon at the outer envelope membrane of chloroplasts 159; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Required for chloroplast biogenesis. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. TOC159 subfamily (1503 aa)
     
 
0.841
AT1G63900
E3 Ubiquitin ligase family protein; E3 ubiquitin-protein ligase involved in the regulation of protein import in the chloroplast. Associates with TOC complexes and mediates ubiquitination of TOC components, promoting their degradation via the ubiquitin-proteasome system (UPS). Plays a role in the reorganization of the TOC machinery. Involved in a mechanism that regulates plastid biogenesis via UPS. Promotes stress tolerance by depleting the chloroplast protein import apparatus, which limits photosystem assembly and the potential for reactive oxygen species (ROS) formation. May act as ne [...] (347 aa)
       
 
  0.828
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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