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TPK4 protein (Arabidopsis thaliana) - STRING interaction network
"TPK4" - Outward rectifying potassium channel protein in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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TPK4Outward rectifying potassium channel protein; Encodes AtTPK4, a member of the Arabidopsis thaliana K+ channel family of AtTPK/KCO proteins. AtTPK4 is targeted to the plasma membrane. In contrast other members of the AtTPK proteins are located in tonoplast. AtTPK4 forms a voltage-independent K+ channel that is blocked by extracellular calcium ions. May form homomeric ion channels in vivo (284 aa)    
Predicted Functional Partners:
KT5
Encodes AKT5, a member of the Shaker family potassium ion (K+) channel. This family includes five groups based on phylogenetic analysis (FEBS Letters (2007) 581- 2357)- I (inward rectifying channel)- AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel)- KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel)- AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation)- KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel)- SKOR (AT3G02850) and GORK (AT5G3750 [...] (880 aa)
     
 
  0.850
SPIK
Shaker pollen inward K+ channel; Encodes SPIK, a member of the Shaker family potassium ion (K+) channel. This family includes five groups based on phylogenetic analysis (FEBS Letters (2007) 581- 2357)- I (inward rectifying channel)- AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel)- KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel)- AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation)- KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel)- SK [...] (888 aa)
     
 
  0.848
TPC1
Two pore calcium channel protein 1; Encodes a depolarization-activated Ca(2+) channel. Anti-sense experiments with this gene as well as Sucrose-H(+) symporters and complementation of yeast sucrose uptake mutant cch1 suggest that this protein mediates a voltage-activated Ca(2+ )influx. Mutants lack detectable SV channel activity suggesting TPC1 is essential component of the SV channel. Patch clamp analysis of loss of function mutation indicates TPC1 does not affect Ca2+ signaling in response to abiotic and biotic stress; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) famil [...] (733 aa)
           
  0.741
ORF143
Uncharacterized mitochondrial protein AtMg00120; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in endomembrane system (143 aa)
           
  0.693
SKOR
STELAR K+ outward rectifier; Encodes SKOR, a member of Shaker family potassium ion (K+) channel. This family includes five groups based on phylogenetic analysis (FEBS Letters (2007) 581- 2357)- I (inward rectifying channel)- AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel)- KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel)- AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation)- KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel)- SKOR (AT3G [...] (828 aa)
       
 
  0.667
HKT1
High-affinity K+ transporter 1; Sodium transporter protein, which plays a central role in plant tolerance to salt. Upon prolongated exposure to high concentrations, Na(+) translocates from the roots to the transpiring leaves where it can increase to toxic level. Involved in Na(+) recirculation from shoots to roots, probably by mediating Na(+) loading into the phloem sap in shoots and unloading in roots, thereby removing large amounts of Na(+) from the shoot. Does not transport K(+) but regulates K(+) nutrient status via its ability to facilitate Na(+) homeostasis. Probably not involved [...] (506 aa)
       
 
  0.652
KT2/3
Potassium channel AKT2/3; Encodes AKT2, a photosynthate- and light-dependent inward rectifying potassium channel with unique gating properties that are regulated by phosphorylation. Expressed in guard cell protoplasts and in the phloem and xylem of aerial portions of the plant. The channel can coassemble with another K+ channel, KAT1, in vitro. In guard cells, AKT2/3 is responsible for the Ca2+ sensitivity of the K+ uptake channel. In the phloem, it regulates the sucrose/H+ symporters via the phloem potential. AKT2 belongs to the Shaker family K+ channels which include the followi [...] (802 aa)
       
 
  0.646
VAMP723
Vesicle-associated membrane protein 723; Involved in the targeting and/or fusion of transport vesicles to their target membrane (217 aa)
           
  0.601
AKT1
Potassium channel AKT1; Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpol [...] (857 aa)
       
 
  0.592
CNGC13
Putative cyclic nucleotide-gated ion channel 13; Member of Cyclic nucleotide gated channel family; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family (696 aa)
       
 
  0.583
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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