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PEX6 protein (Arabidopsis thaliana) - STRING interaction network
"PEX6" - Peroxisome biogenesis protein 6 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PEX6Peroxisome biogenesis protein 6; Involved in peroxisomal-targeting signal one (PTS1) and peroxisomal-targeting signal two (PTS2) protein import. Required for jasmonate biosynthesis. Necessary for the developmental elimination of obsolete peroxisome matix proteins. May form heteromeric AAA ATPase complexes required for the import of proteins. May be involved in PEX5 recycling (941 aa)    
Predicted Functional Partners:
PEX1
Peroxisome biogenesis protein 1; Involved in PTS1- and PTS2-dependent protein import into peroxisomes. May form heteromeric AAA ATPase complexes required for the import of proteins (1130 aa)
   
0.995
PEX5
Peroxisome biogenesis protein 5; Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal "SKL" targeting signal. The mechanism of transport has been worked out in other organisms- The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX1 [...] (728 aa)
     
 
  0.994
PEX10
Peroxisome biogenesis factor 10; Involved in the formation of peroxisomes, lipid bodies and protein bodies. Required for normal-shaped peroxisomes that can physically associate with the outer membrane of the chloroplast envelope. Not involved in beta-oxidation and glyoxylate cycle. Acts as an E3 ubiquitin-protein ligase; Belongs to the pex2/pex10/pex12 family (381 aa)
     
 
  0.993
PEX12
Peroxisome biogenesis protein 12; Required for peroxisome biogenesis and for PTS1- and PTS2-dependent protein import into peroxisomes. Essential for the peroxisomal targeting of PEX7. Required for the export/release of receptors on the peroxisome membrane. Acts as an E3 ubiquitin- protein ligase involved in monoubiquitination of PEX5 (393 aa)
     
 
  0.993
PEX7
Peroxisome biogenesis protein 7; Encodes the peroxisomal targeting signal type 2 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS2 consensus sequence (RLX5HL or a variant) within the first 30 or so amino acids. RNAi experiments suggest that PEX7 is necessary for the maintenance of glyoxysomal but not leaf peroxisomal function; Belongs to the WD repeat peroxin-7 family (317 aa)
     
   
  0.992
APEM9
3-phosphoinositide-dependent protein kinase-1, putative; Involved in peroxisome biogenesis and matrix protein import. Required for pollen maturation and in vivo germination via its role in peroxisomal function, which partially involves jasmonic acid biosynthesis. Transported to peroxisomes via the interaction with PEX19-1. Required for peroxisomal protein import by acting as an anchoring protein for the AAA ATPase complex, which consists of PEX1 and PEX6 (333 aa)
       
 
  0.989
PEX14
Peroxisomal membrane protein PEX14; Controls intracellular transport of both PTS1- and PTS2- containing proteins. Required for the proper targeting of PEX7 to the peroxisome (507 aa)
     
 
  0.961
PEX22
Peroxisome biogenesis protein 22; Interacts with PEX4 in a yeast two-hybrid. The PEX4 and PEX22 pair may be important during the remodeling of peroxisome matrix contents as glyoxysomes transition to leaf peroxisomes (283 aa)
           
  0.953
PEX13
Peroxisomal membrane protein 13; Involved in PTS1- and PTS2-dependent protein import into peroxisomes. Required for PTS1- dependent protein import into pollen peroxisomes. Acts as a docking factor on peroxisomal membranes. Required for the proper targeting of PEX7 to the peroxisome. Required for the export/release of receptors on the peroxisome membrane. Essential for pollen-tube discharge that take place only in the presence of functional peroxisomes in either the male or the female gametophyte; Belongs to the peroxin-13 family (304 aa)
           
  0.952
PEX19-2
Peroxisome biogenesis protein 19-2; Contributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins. Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer; Belongs to the peroxin-19 family (245 aa)
     
 
  0.949
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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