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RRP4 protein (Arabidopsis thaliana) - STRING interaction network
"RRP4" - Ribosomal RNA processing 4 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RRP4Ribosomal RNA processing 4; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is an active and distributive 3’->5’ exonuclease requiring a free 3’-OH on the substrate and releasing nucleoside 5’-monophosphates (PubMed-11809881). Required for normal embryo development (PubMed-18160042) (322 aa)    
Predicted Functional Partners:
RRP41
Exonuclease RRP41 (RRP41); Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is a processive phosphorolytic exonuclease and requires a single-stranded poly(A) tail on the substrate RNA for its activity. Can complement the growth defect of a yeast mutant lacking RRP41 exonuclease (PubMed-10930416). Required for normal development of female gametophytes (PubMed-18160042) (241 aa)
   
  0.999
AT3G46210
Exosome complex component RRP46; Probable component of the exosome 3’->5’ exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’-untranslated regions (239 aa)
   
  0.999
AT3G07750
3’-5’-exoribonuclease family protein (286 aa)
 
  0.999
RRP45a
Ribonuclease PH45A; Probable 3’->5’ exoribonuclease involved in the regulation of cuticular wax biosynthesis. Can perform exosomal functions and partially complement the yeast rrp45 null mutant (307 aa)
 
  0.999
CER7
ECERIFERUM 7; Probable 3’->5’ exoribonuclease involved in the regulation of cuticular wax biosynthesis by controlling the expression of CER3. May act by degrading a specific mRNA species encoding a negative regulator of CER3 transcription. Can perform exosomal functions and complement the yeast rrp45 null mutant (438 aa)
 
  0.999
AT1G60080
3’-5’-exoribonuclease family protein (302 aa)
 
  0.999
AT2G25355
PNAS-3 related (241 aa)
     
  0.999
AT5G35910
Exosome complex exonuclease RRP6; Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed-23555312, PubMed-25211139). Involved in association with RRP6L1 in the silencing of the solo LTR locus. Controls levels of non-coding RNAs (ncRNAs) from the solo LTR locus. Seems to function independently of the RNA- mediated gene silencing (RdDM) pathway (PubMed-23555312). Functions redundantly with RRP6L1 in the regulation of FLC locus. Participates in the maintenance of trimethylated ’Lys-27’ (H3K27me3) at FLC locus via the regulation of antisense long non- codin [...] (870 aa)
     
  0.999
AT1G54440
RRP6-like protein 1; Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed-23555312, PubMed-24726328, PubMed-24719467, PubMed-25211139). Involved in transcriptional gene silencing (TGS). Plays a role for DNA methylation in the RNA- directed DNA methylation (RdDM) pathway. Contributes to the methylation status of the retrotransposon SN1. Required for DNA methylation only at a subset of RdDM target loci (PubMed-24719467). Plays a regulatory role in RdDM through retention of non-coding RNAs (ncRNAs) in normal cells. Helps to retain Pol V-transcribed RNAs [...] (639 aa)
     
  0.999
RRP41L
RRP41 like; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is a processive phosphorolytic exonuclease and requires a single-stranded poly(A) tail on the substrate RNA for its activity (By similarity). Plays an important role in seed germination and early seedling growth by mediating specific cytoplasmic mRNA decay of transcripts coding for the abscisic acid (ABA) biosynthetic enzymes NCED5 and NCED6, and the ABA signaling transcription f [...] (256 aa)
 
  0.999
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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