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At1g03780 protein (Arabidopsis thaliana) - STRING interaction network
"At1g03780" - Targeting protein for XKLP2 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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At1g03780Targeting protein for XKLP2; Regulates prospindle assembly during late prophase and at the onset of mitosis, before nuclear envelope breakdown (NEB). Is exported from the nucleus shortly before NEB and organized into two polar crescents. After NEB, is progressively associated with the forming spindle. Probably mediates AUR1 activation and localization to spindle microtubules. Has a microtubule binding capability and is able to trigger microtubule assembly induced by RanGTP in a heterologous system. Not involved in phragmoplast assembly, nuclear envelope reformation, and cortical microt [...] (790 aa)    
Predicted Functional Partners:
AUR1
Ataurora1; Phosphorylates specifically ’Ser-10’ of histone H3 in vitro and colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Colocalizes also with gamma-tubulin and function in microtubule organizing centers (MTOCs). In contrast with the mammalian B-type Aurora, AUR1 has no kinase activity toward ’Ser-28’ of histone H3 (294 aa)
     
   
  0.890
TOPII
Topoisomerase II; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1473 aa)
     
   
  0.832
ATK5
Kinesin 5; Kinesin that supports microtubule movement in an ATP- dependent manner and that functions as a minus-end directed motor as well as a plus-end tracking protein. During mitosis, is involved in early spindle assembly. Participates in the capture of antiparallel interpolar microtubules and helps in generating force to coalign microtubules (790 aa)
     
   
  0.820
IMPA-1
Importin alpha isoform 1; Binds to conventional NLS motifs with high affinity in the absence of an importin beta subunit. Mediates nuclear protein import across the nuclear envelope in vitro in the absence of exogenously added importin beta subunit (PubMed-10428841). Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation (PubMed-18836040) (532 aa)
       
 
  0.788
HIK
HINKEL; Probable plus end-directed motor protein that functions in a MAP kinase signaling pathway (ANP1-MKK6-MPK4), which is essential for somatic cell cytokinesis, especially for the cell- plate formation and its expansion. Regulates the activity and the localization of ANP1, probably by association through the non- catalytic region of the kinase. Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis (974 aa)
     
        0.779
BUBR1
Checkpoint serine/threonine-protein kinase; Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C (By similarity) (396 aa)
     
   
  0.776
MAP65-2
Microtubule-associated protein 65-2; Microtubule-associated protein that stabilize microtubules (MT). Involved in the regulation of MT organization and dynamics. Confers MT resistance to the drug propyzamide and cold conditions (578 aa)
     
   
  0.758
3xHMG-box2
3xHigh Mobility Group-box2 (456 aa)
     
        0.757
CYCB2;4
CYCLIN B2;4 (431 aa)
     
        0.716
AT3G51280
Tetratricopeptide repeat domain-containing protein; Probably involved in the regulation of cell division (430 aa)
     
        0.708
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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