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At1g03780 protein (Arabidopsis thaliana) - STRING interaction network
"At1g03780" - Targeting protein for XKLP2 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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At1g03780Targeting protein for XKLP2; Regulates prospindle assembly during late prophase and at the onset of mitosis, before nuclear envelope breakdown (NEB). Is exported from the nucleus shortly before NEB and organized into two polar crescents. After NEB, is progressively associated with the forming spindle. Probably mediates AUR1 activation and localization to spindle microtubules. Has a microtubule binding capability and is able to trigger microtubule assembly induced by RanGTP in a heterologous system. Not involved in phragmoplast assembly, nuclear envelope reformation, and cortical microt [...] (790 aa)    
Predicted Functional Partners:
AUR1
Serine/threonine-protein kinase Aurora-1; Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle. It specifically phosphorylates Ser10 of hist [...] (294 aa)
     
 
  0.998
AUR2
Serine/threonine-protein kinase Aurora-2; Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle (288 aa)
     
 
  0.987
AUR3
Serine/threonine-protein kinase Aurora-3; Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle. The protein is concentrated in nuclear dots [...] (288 aa)
     
 
  0.985
MAD2
Mitotic spindle checkpoint protein MAD2; Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (209 aa)
     
   
  0.980
AT2G28620
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules (By similarity). Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis (1042 aa)
     
   
  0.971
TOPII
DNA topoisomerase 2; Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues (1473 aa)
     
   
  0.970
BUBR1
BUB1-related (BUB1- budding uninhibited by benzymidazol 1); Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C (By similarity) (396 aa)
     
   
  0.969
AT4G14330
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Probable plus end-directed motor protein that may contribute to the transport of Golgi-derived vesicles in the phragmoplast (869 aa)
     
   
  0.968
AT2G36200
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules (By similarity). Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis (By similarity) (1040 aa)
     
   
  0.967
3xHMG-box2
HMG (high mobility group) box protein; Its function is described as sequence-specific DNA binding transcription factor activity; Located in nucleus, chloroplast; Expressed in 20 plant structures; Expressed during 11 growth stages; Contains the following InterPro domains- High mobility group, superfamily (InterPro-IPR009071), High mobility group, HMG1/HMG2 (InterPro-IPR000910); BEST Arabidopsis thaliana protein match is- HMG (high mobility group) box protein (TAIR-AT4G11080.1); Has 73209 Blast hits to 39847 proteins in 2254 species- Archae - 389; Bacteria - 7210; Metazoa - 37524; Fungi [...] (456 aa)
     
        0.965
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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