• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
PKT4 protein (Arabidopsis thaliana) - STRING interaction network
"PKT4" - 3-ketoacyl-CoA thiolase 1, peroxisomal in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKT43-ketoacyl-CoA thiolase 1, peroxisomal; Involved in fatty-acid beta-oxidation prior to gluconeogenesis during germination and subsequent seedling growth. Implicated in jasmonic acid (JA) biosynthesis (By similarity); Belongs to the thiolase family (443 aa)    
Predicted Functional Partners:
HMGS
Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation (461 aa)
   
  0.991
PEX7
Peroxisome biogenesis protein 7; Encodes the peroxisomal targeting signal type 2 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS2 consensus sequence (RLX5HL or a variant) within the first 30 or so amino acids. RNAi experiments suggest that PEX7 is necessary for the maintenance of glyoxysomal but not leaf peroxisomal function; Belongs to the WD repeat peroxin-7 family (317 aa)
     
  0.990
AIM1
Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1; Involved in peroxisomal fatty acid beta-oxidation. Required for wound-induced jasmonate biosynthesis. Possesses enoyl-CoA hydratase activity against short chain substrates (C4- C6) and 3-hydroxyacyl-CoA dehydrogenase activity against chains of variable sizes (C6-C16). Possesses cinnamoyl-CoA hydratase activity and is involved in the peroxisomal beta-oxidation pathway for the biosynthesis of benzoic acid (BA). Required for the accumulation in seeds of benzoylated glucosinolates (BGs) and substituted hydroxybenzoylated c [...] (721 aa)
  0.984
MFP2
Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2; Involved in peroxisomal fatty acid beta-oxidation during seed germination. Possesses enoyl-CoA hydratase activity against long chain substrates (C14-C18) and 3-hydroxyacyl-CoA dehydrogenase activity against chains of variable sizes (C6-C18). Possesses 3- hydroxy-3-phenylpropionyl-CoA dehydrogenase activity and is involved in the peroxisomal beta-oxidation pathway for the biosynthesis of benzoic acid (BA). Required for the accumulation in seeds of substituted hydroxybenzoylated choline esters, which are BA-containing se [...] (725 aa)
  0.972
ACX5
Putative peroxisomal acyl-coenzyme A oxidase 1.2; Encodes an acyl-CoA oxidase. Involved in jasmonate biosynthesis. Expressed uniformly in seedlings and throughout development (664 aa)
   
 
  0.971
ACX1
Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of both long- and medium- chain acyl-CoAs to 2-trans-enoyl-CoAs. Most active with C14-CoA. Activity on long-chain mono-unsaturated substrates is 40% higher than with the corresponding saturated substrates. Seems to be an important factor in the general metabolism of root tips. May be involved in the biosynthesis of jasmonic acid (664 aa)
   
 
  0.969
AT2G26800
Hydroxymethylglutaryl-CoA lyase, mitochondrial; Involved in the catabolism of branched amino acids such as leucine (468 aa)
   
 
  0.960
ACX3
Acyl-coenzyme A oxidase 3, peroxisomal; Catalyzes the desaturation of medium-chain acyl-CoAs to 2-trans-enoyl-CoAs. Active on C8-0- to C14-0-CoA with a maximal activity on C12-0-CoA (675 aa)
   
 
  0.958
AT3G15290
3-hydroxybutyryl-CoA dehydrogenase-like protein; 3-hydroxyacyl-CoA dehydrogenase family protein; Its function is described as in 7 functions; Involved in fatty acid metabolic process, metabolic process; Located in peroxisome; Expressed in 24 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- Dehydrogenase, multihelical (InterPro-IPR013328), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro-IPR008927), 3-hydroxyacyl-CoA dehydrogenase, NAD binding (InterPro-IPR006176), 3-hydroxyacyl-CoA dehydrogenase, C-terminal (InterPro-IPR006108), 3 [...] (294 aa)
 
 
  0.953
ECH2
Encodes a monofunctional enoyl-CoA hydratase 2, involved in the degradation of even cis-unsaturated fatty acids, gene expression is enhanced during the first 2 days of germination, as well as in senescent leaves (309 aa)
   
 
  0.952
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]