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PDIL2-2 protein (Arabidopsis thaliana) - STRING interaction network
"PDIL2-2" - Encodes a protein disulfide isomerase-like in Arabidopsis thaliana
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Predicted Interactions
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textmining
co-expression
protein homology
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PDIL2-2Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). AtIRE1-2 does not appear to be required for this response, but the atbzip60 mutant has a diminished response (447 aa)    
Predicted Functional Partners:
CNX1
Calnexin homolog 1; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity) (530 aa)
     
 
  0.979
SHD
Chaperone protein htpG family protein; Encodes an ortholog of GRP94, an ER-resident HSP90-like protein and is involved in regulation of meristem size and organization. Single and double mutant analyses suggest that SHD may be required for the correct folding and/or complex formation of CLV proteins. Lines carrying recessive mutations in this locus exhibits expanded shoot meristems, disorganized root meristems, and defective pollen tube elongation. Transcript is detected in all tissues examined and is not induced by heat. Endoplasmin supports the protein secretory pathway and has a rol [...] (823 aa)
     
 
  0.974
PDIL1-2
Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). AtIRE1-2 does not appear to be required for this response, but the atbzip60 mutant has a diminished response (508 aa)
     
 
0.931
ATERDJ3B
DNAJ heat shock family protein; J domain protein localized in ER lumen. Can partially compensate for the growth defect in jem1 scj1 mutant yeast. Forms a complex SDF2-ERdj3B-BiP that is required for the proper accumulation of the surface-exposed leucine-rich repeat receptor kinases EFR. EFR is involved in PAMP (pathogen associated molecular patterns) triggered immunity (346 aa)
     
 
  0.926
AT5G07340
Calreticulin family protein; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity) (540 aa)
     
 
  0.922
SDF2
Stromal cell-derived factor 2-like protein precursor; Involved in the endoplasmic reticulum (ER) protein quality control and unfolded protein response. May be involved in the quality control of glycoproteins. Forms a complex in the ER with ERDJ3B and MED37A/BIP1 which is required for the proper accumulation and function of the surface-exposed leucine-rich repeat receptor kinases EFR involved in pathogen-associated molecular pattern (PAMP) triggered immunity (218 aa)
     
 
  0.888
BIP2
Mediator of RNA polymerase II transcription subunit 37f; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general [...] (668 aa)
     
 
  0.888
AT4G29520
Uncharacterized protein AT4g29520; Located in endoplasmic reticulum, plasma membrane; Expressed in 23 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- Saposin B (InterPro-IPR008139); Has 137 Blast hits to 137 proteins in 50 species- Archae - 2; Bacteria - 0; Metazoa - 41; Fungi - 10; Plants - 36; Viruses - 0; Other Eukaryotes - 48 (source- NCBI BLink) (306 aa)
     
        0.876
ERO1
Endoplasmic reticulum oxidoreductins 1; Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI to transfer oxidizing equivalent. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a signific [...] (469 aa)
     
  0.866
AT4G16660
Heat shock protein 70 (Hsp 70) family protein; Its function is described as ATP binding; Located in plasma membrane, chloroplast; Expressed in 24 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Heat shock protein 70, conserved site (InterPro-IPR018181), Heat shock protein Hsp70 (InterPro-IPR001023), Heat shock protein 70 (InterPro-IPR013126); BEST Arabidopsis thaliana protein match is- heat shock protein 70 (Hsp 70) family protein (TAIR-AT1G11660.1); Has 30201 Blast hits to 17322 proteins in 780 species- Archae - 12; Bacteria - 1396; Metazo [...] (867 aa)
     
 
  0.865
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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