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MAPKKK18 protein (Arabidopsis thaliana) - STRING interaction network
"MAPKKK18" - Mitogen-activated protein kinase kinase kinase 18 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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MAPKKK18Mitogen-activated protein kinase kinase kinase 18; Component of the abscisic acid (ABA) signaling pathway that acts as ABA signal transducer in the context of abiotic stresses. Triggers MPK1, MPK2, MPK7 and MPK14 activation in a MKK3-dependent manner and MPK6 activation in a MKK3-independent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module. Positive regulator of ABA responses leading to the induction of gene expression (e.g. RD29B and RAB18) and involved in various responses including stomatal development, stomatal movement, inhibition of germination and root growt [...] (339 aa)    
Predicted Functional Partners:
MKK3
Mitogen-activated protein kinase kinase 3; MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression. Activates by phosphorylation the downstream MPK6, MPK7 and MPK8. MKK3-MPK7 module acts as a positive regulator of PR1 gene expression. MKK3-MPK8 module negatively regulates ROS accumulation through controlling expression of the RBOHD gene. Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Activator of the C group MAP kinases. [...] (520 aa)
   
 
0.974
MKK2
Mitogen-activated protein kinase kinase 2; MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Plays a role in abiotic stress tolerance and plant disease resistance through activation of MPK4 and MPK6 by phosphorylation. Acts redundantly with MKK1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily (372 aa)
   
 
0.944
MEK1
Mitogen-activated protein kinase kinase 1; MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Activates by phosphorylation the downstream MPK4. Acts redundantly with MKK2. MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H(2)O(2) production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination; B [...] (354 aa)
   
 
0.939
MKK6
Mitogen-activated protein kinase kinase 6; The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. MKK6-MPK13 module positively regulates lateral root formation. Phosphorylates and activates MPK4. Activates MPK5 and MPK13 in vitro (356 aa)
   
 
0.937
MAPKKK17
Mitogen-activated protein kinase kinase kinase 17; Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Triggers MPK7 activation in a MKK3-dependent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family (372 aa)
   
 
0.841
AT5G66710
Protein kinase superfamily protein; Its function is described as protein serine/threonine/tyrosine kinase activity, kinase activity; Involved in protein amino acid phosphorylation; Located in plasma membrane; Expressed in 9 plant structures; Expressed during 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; Contains the following InterPro domains- Protein kinase, catalytic domain (InterPro-IPR000719), Serine/threonine-protein kinase, ATN1-like (InterPro-IPR015784), Serine-threonine/tyrosine-protein kinase (Inter [...] (405 aa)
   
 
  0.707
AT5G50180
Protein kinase superfamily protein; Its function is described as protein serine/threonine/tyrosine kinase activity, kinase activity; Involved in protein amino acid phosphorylation; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Protein kinase, ATP binding site (InterPro-IPR017441), Protein kinase, catalytic domain (InterPro-IPR000719), Serine/threonine-protein kinase, ATN1-like (InterPro-IPR015784), Serine-threonine/tyrosine-protein kinase (InterPro-IPR001245), Protein kinase-like domain (InterPro-IPR011009), Serine/threoni [...] (346 aa)
   
 
  0.700
HAB1
Protein phosphatase 2C 16; Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought (511 aa)
     
 
  0.690
AT5G04170
Calcium-binding EF-hand family protein; Potential calcium sensor (354 aa)
     
   
  0.680
AT5G40540
Protein kinase superfamily protein; Its function is described as protein serine/threonine/tyrosine kinase activity, kinase activity; Involved in protein amino acid phosphorylation; Located in cellular_component unknown; Expressed in 13 plant structures; Expressed during 7 growth stages; Contains the following InterPro domains- Protein kinase, ATP binding site (InterPro-IPR017441), Protein kinase, catalytic domain (InterPro-IPR000719), Serine/threonine-protein kinase, ATN1-like (InterPro-IPR015784), Serine-threonine/tyrosine-protein kinase (InterPro-IPR001245), Protein kinase-like domai [...] (353 aa)
   
 
  0.677
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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