• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
URH2 protein (Arabidopsis thaliana) - STRING interaction network
"URH2" - Probable uridine nucleosidase 2 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
URH2Probable uridine nucleosidase 2; Involved in pyrimidine breakdown; Belongs to the IUNH family (322 aa)    
Predicted Functional Partners:
AT5G28050
Cytidine/deoxycytidylate deaminase family protein; Its function is described as hydrolase activity, zinc ion binding, catalytic activity; Located in cellular_component unknown; Expressed in 24 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- APOBEC/CMP deaminase, zinc-binding (InterPro-IPR016192), CMP/dCMP deaminase, zinc-binding (InterPro-IPR002125), Cytidine deaminase-like (InterPro-IPR016193); BEST Arabidopsis thaliana protein match is- Cytidine/deoxycytidylate deaminase family protein (TAIR-AT3G05300.1); Has 7983 Blast hits to 7983 prote [...] (204 aa)
         
  0.904
PYD1
Dihydropyrimidine dehydrogenase (NADP(+)), chloroplastic; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate and the reduction of thymine to 5,6- dihydrothymine (DHT). Involved in the recycling of nitrogen from nucleobases to general nitrogen metabolism; Belongs to the dihydropyrimidine dehydrogenase family (426 aa)
           
  0.865
UKL5
Uridine kinase-like protein 5; One of the homologous genes predicted to encode proteins with UPRT domains (Uracil phosphoribosyltransferase). Five of these genes (At5g40870, At3g27190, At1g55810, At4g26510 and At3g27440) show a high level of identity, and are annotated as also containing a N-terminal uracil kinase (UK) domain. These genes are referred to as UKL1 (UK-like 1), UKL2, UKL3, UKL4 and UKL5, respectively; In the C-terminal section; belongs to the UPRTase family (465 aa)
     
 
  0.825
BETA-UP
Beta-ureidopropionase; Converts N-carbamoyl-beta-aminoisobutyrate and N- carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide. Involved in the recycling of nitrogen from nucleobases to general nitrogen metabolism (408 aa)
           
  0.773
PYD2
Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamoyl-alanine and of 5,6-dihydrothymine to N-carbamoyl-amino isobutyrate. Involved in the recycling of nitrogen from nucleobases to general nitrogen metabolism; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family (531 aa)
           
  0.757
UKL2
Uridine kinase-like protein 2, chloroplastic; One of the homologous genes predicted to encode proteins with UPRT domains (Uracil phosphoribosyltransferase). Five of these genes (At5g40870, At3g27190, At1g55810, At4g26510 and At3g27440) show a high level of identity, and are annotated as also containing a N-terminal uracil kinase (UK) domain. These genes are referred to as UKL1 (UK-like 1), UKL2, UKL3, UKL4 and UKL5, respectively; In the C-terminal section; belongs to the UPRTase family (483 aa)
     
 
  0.733
UK/UPRT1
Uridine kinase/uracil phosphoribosyltransferase 1; Involved in the pyrimidine salvage pathway. The uracil phosphoribosyltransferase (UPRT) activity, that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate, is unsure; In the N-terminal section; belongs to the uridine kinase family (486 aa)
     
 
  0.724
UKL4
Uridine kinase-like protein 4; One of the homologous genes predicted to encode proteins with UPRT domains (Uracil phosphoribosyltransferase). Five of these genes (At5g40870, At3g27190, At1g55810, At4g26510 and At3g27440) show a high level of identity, and are annotated as also containing a N-terminal uracil kinase (UK) domain. These genes are referred to as UKL1 (UK-like 1), UKL2, UKL3, UKL4 and UKL5, respectively; In the C-terminal section; belongs to the UPRTase family (469 aa)
     
 
  0.724
UKL3
Uridine kinase-like protein 3; One of the homologous genes predicted to encode proteins with UPRT domains (Uracil phosphoribosyltransferase). Five of these genes (At5g40870, At3g27190, At1g55810, At4g26510 and At3g27440) show a high level of identity, and are annotated as also containing a N-terminal uracil kinase (UK) domain. These genes are referred to as UKL1 (UK-like 1), UKL2, UKL3, UKL4 and UKL5, respectively; In the C-terminal section; belongs to the UPRTase family (466 aa)
     
 
  0.724
PYRD
Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily (460 aa)
           
  0.648
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (7%) [HD]