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NTH2 protein (Arabidopsis thaliana) - STRING interaction network
"NTH2" - Endonuclease III in Arabidopsis thaliana
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NTH2Endonuclease III; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines (386 aa)    
Predicted Functional Partners:
ARP
Apurinic endonuclease-redox protein; Repairs oxidative DNA damages, seems also to act as a redox factor (PubMed-7512729). Is multifunctional and may be involved both in DNA repair and in the regulation of transcription (PubMed-7512729). Exhibits apurinic/apyrimidinic (AP) endonuclease activity (PubMed-25569774, PubMed-21781197, PubMed-25228464). Catalyzes the conversion of 3’-phosphor-alpha,beta-unsaturated aldehyde (3’-PUA) to 3’-OH (PubMed-25228464). May be involved in base excision repair in chloroplasts (PubMed-19372224). According to a report, has a significant in vitro 3’-phospha [...] (536 aa)
     
  0.975
AT3G48425
DNAse I-like superfamily protein; Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting (PubMed-25569774). According to a report, displays also an in vitro 3’-phosphatase activity (PubMed-25569774). According to another report, has no in vitro 3’-phosphatase activity (PubMed-25228464). Catalyzes the conversion of the 3’-blocking groups 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) generated by ROS1 to 3’-OH (PubMed-25228464, PubMed-25569774). Has a strong non-specific affinity to DNA (PubMed-25228464). Redundant with APE2 and at least [...] (364 aa)
     
  0.971
ATNTH1
Endonuclease III; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines (379 aa)
   
   
0.903
AT3G47830
DNA glycosylase superfamily protein (293 aa)
         
    0.800
UVH1
DNA repair endonuclease UVH1; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). Involved in repair of UV light, and probably oxidative damage. The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase (956 aa)
     
 
  0.776
LIG1
DNA ligase 1; Essential protein. DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Involved in repair of both single strand breaks (SSBs) and double strand breaks (DSBs). Required in the endosperm for embryogenesis, probably to repair DNA-breaks generated by DME (790 aa)
     
   
  0.746
AT1G75230
DNA-3-methyladenine glycosylase II (394 aa)
       
 
  0.742
AT1G19480
DNA glycosylase superfamily protein (382 aa)
       
 
  0.742
UVH3
DNA repair protein UVH3; Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3’-incision step in NER. Seems to play a role in senescence program (1479 aa)
   
 
  0.737
AT3G61030
Calcium-dependent lipid-binding (CaLB domain) family protein (509 aa)
     
 
  0.731
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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