Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
B3 domain-containing protein At1g05920; Its function is described as DNA binding; Involved in regulation of transcription, DNA-dependent; Located in cellular_component unknown; Contains the following InterPro domains- Protein of unknown function DUF313 (InterPro-IPR005508), Transcriptional factor B3 (InterPro-IPR003340); BEST Arabidopsis thaliana protein match is- Domain of unknown function (DUF313) (TAIR-AT3G24850.1); Has 196 Blast hits to 185 proteins in 22 species- Archae - 0; Bacteria - 7; Metazoa - 15; Fungi - 10; Plants - 139; Viruses - 0; Other Eukaryotes - 25 (source- NCBI BLink) (315 aa)
Sorry, there are no predicted associations at the current settings.
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NCBI taxonomy Id: 3702 Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress