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STN1 protein (Arabidopsis thaliana) - STRING interaction network
"STN1" - CST complex subunit STN1 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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STN1CST complex subunit STN1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves (PubMed-19064932). Associates with enzymatically active telomerase (PubMed-25329641). Plays a genomewide role in DNA replication and facilitates re- replication at non-telomeric loci (PubMed-25299252) (160 aa)    
Predicted Functional Partners:
CTC1
CST complex subunit CTC1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves (PubMed-19854131). Associates with enzymatically active telomerase (PubMed-25329641) (1274 aa)
       
 
  0.997
MDO1
Uncharacterized protein; Required for the maintenance of meristems and stem cells through the reduction of DNA damage (PubMed-21781195). Promotes telomere integrity by maintaining telomere length and proper architecture of the chromosome terminus (PubMed-23572541). Negatively regulates telomerase repeat addition processivity (PubMed-23572541). Hampers contacts between enzymatically active telomerase and CST complex (PubMed-25329641) (127 aa)
           
  0.983
AtPOT1a
Protection of Telomeres 1a; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for positive telomere length regulation. Binds specifically the telomerase RNA template component TER1. Does not bind single-stranded telomeric DNA. Not required to recruit telomerase to telomeres, but stimulates TER1 RNP repeat addition processivity (PubMed-25329641) (467 aa)
       
 
  0.980
TERT
Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Required to prevent genome instability induced by breakage-fusion-bridge (BFB) cycles. Can extend completely non-telomeric sequences using RNA template in vitro (1123 aa)
       
 
  0.932
AtPOT1b
Protection of telomeres 1b; Negatively regulates telomerase activity and participate in telomere end-protection. Does not bind single-stranded telomeric DNA (454 aa)
           
  0.922
NAP57
Homologue of NAP57; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (’psi’) residues may serve to stabilize the conformation of rRNAs (By similarity) (565 aa)
           
  0.739
TRB1
Telomere repeat binding factor 1; Binds preferentially double-stranded telomeric repeats (300 aa)
           
  0.678
PARP1
POLY(ADP-RIBOSE) POLYMERASE 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity) (983 aa)
           
  0.676
KU70
KU70 homolog; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand (621 aa)
           
  0.673
ICU2
INCURVATA2; Polymerase alpha in a complex with DNA primase is a replicative polymerase (1524 aa)
           
  0.670
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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