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STRINGSTRING
MAPKKK13 protein (Arabidopsis thaliana) - STRING interaction network
"MAPKKK13" - Mitogen-activated protein kinase kinase kinase 13 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MAPKKK13Mitogen-activated protein kinase kinase kinase 13; Member of MEKK subfamily; Belongs to the protein kinase superfamily (499 aa)    
Predicted Functional Partners:
MKK2
Mitogen-activated protein kinase kinase 2; MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Plays a role in abiotic stress tolerance and plant disease resistance through activation of MPK4 and MPK6 by phosphorylation. Acts redundantly with MKK1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily (372 aa)
       
0.934
MEK1
Mitogen-activated protein kinase kinase 1; MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Activates by phosphorylation the downstream MPK4. Acts redundantly with MKK2. MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H(2)O(2) production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination; B [...] (354 aa)
       
0.932
MKK6
Mitogen-activated protein kinase kinase 6; The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. MKK6-MPK13 module positively regulates lateral root formation. Phosphorylates and activates MPK4. Activates MPK5 and MPK13 in vitro (356 aa)
       
0.930
CYP94C1
Cytochrome P450, family 94, subfamily C, polypeptide 1; Involved in the oxidation of the plant hormone jasmonoyl-L-isoleucine (JA-Ile), a bioactive phytohormone of the jasmonate-mediated signaling pathway. Converts 12-hydroxy-JA-Ile (12OH-JA-Ile) to the carboxy-derivative 12COOH-JA-Ile. Exerts negative feedback control on JA-Ile levels and plays a role in attenuation of jasmonate responses. Functions also as in-chain fatty acids hydroxylase in vitro. Catalyzes the hydroxylation of 12-hydroxy- jasmonoyl-L-phenylalanine (12OH-JA-Phe) in vitro. Converts 12OH- JA-Phe to the carboxy-derivat [...] (495 aa)
     
   
  0.649
RPM1
NB-ARC domain-containing disease resistance protein; Disease resistance (R) protein that specifically recognizes the AvrRpm1 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is phosphorylated by AvrRpm1. It is then degrade [...] (926 aa)
           
  0.634
CKB2
Casein kinase II subunit beta-2; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis. CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation (282 aa)
           
  0.624
GlcNA.1UT2
Encodes a protein that functions as an N-acetylglucosamine-1-phosphate uridylyltransferase that catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc). This is an essential precursor for glycolipid and glycoprotein synthesis and is also used for regulatory protein modification in signaling pathways. The enzyme can also catalyze the reverse reaction using both UDP-GlcNAc and the less common UDP-N-acetylgalactosamine as substrates. This enzyme can also act on glucose-1-phosphate to produce UDP-glucose (502 aa)
           
  0.624
AT5G66710
Protein kinase superfamily protein; Its function is described as protein serine/threonine/tyrosine kinase activity, kinase activity; Involved in protein amino acid phosphorylation; Located in plasma membrane; Expressed in 9 plant structures; Expressed during 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; Contains the following InterPro domains- Protein kinase, catalytic domain (InterPro-IPR000719), Serine/threonine-protein kinase, ATN1-like (InterPro-IPR015784), Serine-threonine/tyrosine-protein kinase (Inter [...] (405 aa)
     
 
  0.584
AT1G79570
Protein kinase superfamily protein with octicosapeptide/Phox/Bem1p domain; Its function is described as protein serine/threonine/tyrosine kinase activity, protein kinase activity; Involved in protein amino acid phosphorylation; Located in cytosol; Expressed in male gametophyte, pollen tube; Expressed during L mature pollen stage, M germinated pollen stage; Contains the following InterPro domains- Octicosapeptide/Phox/Bem1p (InterPro-IPR000270), Protein kinase, ATP binding site (InterPro-IPR017441), Protein kinase, catalytic domain (InterPro-IPR000719), Serine-threonine/tyrosine-protein [...] (1248 aa)
     
 
  0.573
KMS1
SNARE associated Golgi protein family; Involved in the early secretory pathway. Required for the correct export of secretory products from the endoplasmic reticulum (ER) and involved in the maintenance of ER integrity (416 aa)
           
  0.567
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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