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STRINGSTRING
NPC1 protein (Arabidopsis thaliana) - STRING interaction network
"NPC1" - Non-specific phospholipase C1 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NPC1Non-specific phospholipase C1 (NPC1); Its function is described as hydrolase activity, acting on ester bonds; Located in endomembrane system; Expressed in 23 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Phosphoesterase (InterPro-IPR007312); BEST Arabidopsis thaliana protein match is- non-specific phospholipase C2 (TAIR-AT2G26870.1); Has 30201 Blast hits to 17322 proteins in 780 species- Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source- NCBI BLink) (533 aa)    
Predicted Functional Partners:
AT4G38350
Patched family protein; Its function is described as hedgehog receptor activity; Located in membrane; Expressed in 24 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Niemann-Pick C type protein (InterPro-IPR004765), Patched (InterPro-IPR003392), Sterol-sensing 5TM box (InterPro-IPR000731); BEST Arabidopsis thaliana protein match is- Patched family protein (TAIR-AT1G42470.1) (1297 aa)
           
  0.952
AT1G42470
Patched family protein; Its function is described as hedgehog receptor activity; Located in plasma membrane, membrane; Expressed in 24 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- Niemann-Pick C type protein (InterPro-IPR004765), Patched (InterPro-IPR003392), Sterol-sensing 5TM box (InterPro-IPR000731); BEST Arabidopsis thaliana protein match is- Patched family protein (TAIR-AT4G38350.1); Has 2676 Blast hits to 2177 proteins in 377 species- Archae - 64; Bacteria - 237; Metazoa - 1621; Fungi - 207; Plants - 110; Viruses - 0; Other Eukaryo [...] (1272 aa)
           
  0.952
PLDP1
Phospholipase D zeta 1; Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Phosphatidylcholine-selective. Regulates root- hair morphogenesis. Contributes to the supply of inorganic phosphorus for cell metabolism and diacylglycerol moieties for galactolipid synthesis in phosphorus-starved roots. Involved in root elongation during phosphate limitation (1096 aa)
         
  0.939
PLDP2
Phospholipase D zeta 2; Encodes a member of the PXPH-PLD subfamily of phospholipase D proteins. Regulates vesicle trafficking. Required for auxin transport and distribution and hence auxin responses. This subfamily is novel structurally different from the majority of plant PLDs by having phox homology (PX) and pleckstrin homology (PH) domains. Involved regulating root development in response to nutrient limitation. Plays a major role in phosphatidic acid production during phosphate deprivation. Induced upon Pi starvation in both shoots and roots. Involved in hydrolyzing phosphatidyl [...] (1046 aa)
         
  0.913
VPS34
Encodes a phosphatidylinositol 3-kinase that is expressed in most plant tissues. Defects in VPS34 affect a number of cellular processes. Loss of function mutations are not transmitted through the male gametophyte due to defects in microgametogenesis therefore it is difficult to assess the effects of loss of VPS34 function in the whole plant. Involved in salt-stress responses; Belongs to the PI3/PI4-kinase family (814 aa)
     
 
    0.903
CLS
Cardiolipin synthase (CMP-forming), mitochondrial; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). Cannot catalyze the phosphatidyl group transfer from one PG molecule to another to form CL. Possesses high activity with PG species carrying dioleoyl groups and low activity with species carrying one or two palmitoyl groups. CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochond [...] (341 aa)
         
  0.901
AT3G58830
Haloacid dehalogenase (HAD) superfamily protein; Its function is described as catalytic activity; Located in chloroplast; Expressed in 24 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- HAD-superfamily hydrolase, subfamily IIIA (InterPro-IPR006549), Protein of unknown function DUF2010 (InterPro-IPR019001), HAD-superfamily phosphatase, subfamily IIIA (InterPro-IPR010021); Has 1169 Blast hits to 1165 proteins in 593 species- Archae - 0; Bacteria - 976; Metazoa - 0; Fungi - 84; Plants - 42; Viruses - 0; Other Eukaryotes - 67 (source- NCBI BLink) (343 aa)
         
    0.900
PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family (164 aa)
         
    0.900
PSS1
CDP-diacylglycerol--serine O-phosphatidyltransferase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Is essential for phosphatidylserine (PS) biosynthesis and PE seems to be the most plausible substrate. Plays an important role in microspore maturation; Belongs to the CDP-alcohol phosphatidyltransferase class-I family (453 aa)
         
    0.900
LPLAT1
MBOAT (membrane bound O-acyl transferase) family protein; Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine [...] (462 aa)
     
 
  0.882
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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