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HDA08 protein (Arabidopsis thaliana) - STRING interaction network
"HDA08" - Histone deacetylase 8 in Arabidopsis thaliana
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Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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HDA08Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) (377 aa)    
Predicted Functional Partners:
AT2G46040
ARID/BRIGHT DNA-binding domain;ELM2 domain protein; Its function is described as DNA binding; Involved in biological_process unknown; Located in intracellular; Expressed in sperm cell, male gametophyte, cultured cell, seed, pollen tube; Expressed during M germinated pollen stage, E expanded cotyledon stage; Contains the following InterPro domains- ELM2 (InterPro-IPR000949), ARID/BRIGHT DNA-binding domain (InterPro-IPR001606); BEST Arabidopsis thaliana protein match is- ARID/BRIGHT DNA-binding domain;ELM2 domain protein (TAIR-AT4G11400.1); Has 198 Blast hits to 184 proteins in 31 specie [...] (562 aa)
       
 
  0.961
hda17
Histone deacetylase 17; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) (158 aa)
     
 
  0.942
hda10
Putative histone deacetylase 10; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) (142 aa)
     
 
  0.912
SDG20
Histone-lysine N-methyltransferase SUVR3; Histone methyltransferase (354 aa)
   
 
  0.886
AT3G52250
Duplicated homeodomain-like superfamily protein; Encodes a protein with a putative role in mRNA splicing (1656 aa)
     
 
  0.795
MSI2
Transducin family protein / WD-40 repeat family protein; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (415 aa)
     
 
  0.777
TFL2
Chromo domain-containing protein LHP1; Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at ’Lys- 9’ (H3K9me) and ’Lys-27’ (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling a [...] (445 aa)
     
 
  0.775
MSH2
DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers- MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effe [...] (937 aa)
   
      0.775
HAT3.1
Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain; Encodes a member of the PHD-finger homeodomain protein family. The HAT3.1 homeodomain is highly divergent in sequence even at positions that are almost invariable among homeodomains. HAT3.1 shows a preference for the sequence T(A/G)(A/C)ACCA, different from those bound by other homeodomains; Belongs to the PHD-associated homeobox family (723 aa)
     
 
  0.742
HAG1
Encodes a histone acetyltransferase that is plays a role in the determination of the embryonic root-shoot axis. It is also required to regulate the floral meristem activity by modulating the extent of expression of WUS and AG. In other eukaryotes, this protein is recruited to specific promoters by DNA binding transcription factors and is thought to promote transcription by acetylating the N-terminal tail of histone H3. The enzyme has indeed been shown to catalyse primarily the acetylation of H3 histone with only traces of H4 and H2A/B being acetylated. Non-acetylated H3 peptide or an [...] (568 aa)
       
 
  0.720
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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