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CPNIFS protein (Arabidopsis thaliana) - STRING interaction network
"CPNIFS" - Chloroplastic NIFS-like cysteine desulfurase in Arabidopsis thaliana
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Known Interactions
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Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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CPNIFSChloroplastic NIFS-like cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine. Supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Required for the maturation of all plastidic Fe-S proteins and, thus, essential for plant growth; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family (463 aa)    
Predicted Functional Partners:
ISU1
Iron-sulfur cluster assembly protein 1; Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cl [...] (167 aa)
   
 
  0.998
ISU2
Iron-sulfur cluster assembly protein 2; Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cl [...] (163 aa)
   
 
  0.991
ISU3
Iron-sulfur cluster assembly protein 3; Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cl [...] (171 aa)
   
 
  0.989
FH
Frataxin, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Binds to the mitochondrial cysteine desulfurase NIFS1 and increases its activity; Belongs to the frataxin family (187 aa)
     
 
  0.979
CPSUFE
SufE-like protein 1, chloroplastic/mitochondrial; Sulfur acceptor that interacts with and activates the cysteine desulfurases, AtSufS in plastids and AtNifS1 in mitochondria, and both activations are vital during embryogenesis. Dual localization in mitochondria and chloroplasts. Involved in Fe-S cluster biogenesis in mitochondria and plastids. Expressed in all major tissues, with higher expression in green parts. Its expression is light-dependent and regulated at the mRNA level. Activates the cysteine desulfurase activity of CpNifS for chloroplastic iron-sulfur cluster biogenesis; Be [...] (371 aa)
     
   
  0.970
MTO1
Pyridoxal phosphate (PLP)-dependent transferases superfamily protein; Catalyzes the first committed step of methionine (Met) biosynthesis. Catalyzes the formation of L-cystathionine from homoserine esters and L-cysteine, via a gamma-replacement reaction. Substrate preference for cystathionine synthesis is O- phospho-L-homoserine (OPH) > O(4)-succinyl-L-homoserine (OSH) >> O-acetyl-L-homoserine (OAH). Is able, at extremely low rate, to catalyze a gamma-elimination of OPH in the absence of cysteine to produce inorganic phosphate (Pi), 2-oxobutanoate and ammonia (563 aa)
   
 
  0.960
NTRC
NADPH-dependent thioredoxin reductase 3; Thioredoxin reductase (TR) that exhibits both TR and thioredoxin (Trx) activities. Contains a C-terminal functional Trx domain. Functions as an electron donor for plastidial 2-Cys peroxiredoxins and participates in a NADPH-dependent hydrogen peroxide scavenging system in chloroplasts in the dark. Required for chlorophyll biosynthesis and biogenesis of the photosynthetic apparatus. Activates aerobic cyclase which converts Mg- protoporhyrin monomethyl ester into protochlorophyllide. Involved in a light-dependent regulation of starch biosynthesis b [...] (529 aa)
   
 
  0.958
AT1G33320
Pyridoxal phosphate (PLP)-dependent transferases superfamily protein; Catalyzes the first committed step of methionine (Met) biosynthesis. Catalyzes the formation of L-cystathionine from homoserine esters and L-cysteine, via a gamma-replacement reaction; Belongs to the trans-sulfuration enzymes family (412 aa)
   
 
  0.954
NFU2
NifU-like protein 2, chloroplastic; Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins. Required for biogenesis of ferredoxin, a major photosynthetic electron carrier containing [2Fe-2S] cluster. Required for the assembly of photosystem I complex (235 aa)
   
 
  0.953
AT5G06410
DNAJ heat shock N-terminal domain-containing protein; Its function is described as heat shock protein binding, chaperone binding; Involved in protein folding; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Heat shock cognate protein B, C-terminal oligomerisation (InterPro-IPR009073), Heat shock protein DnaJ, N-terminal (InterPro-IPR001623), Co-chaperone Hsc20 (InterPro-IPR004640); Has 1884 Blast hits to 1884 proteins in 890 species- Archae - 0; Bacteria - 1464; Metazoa - 116; Fungi - 101; Plants - 38; Viruses - 0; Other Euk [...] (252 aa)
   
 
  0.953
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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