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VAP27-2 protein (Arabidopsis thaliana) - STRING interaction network
"VAP27-2" - Vamp/synaptobrevin-associated protein 27-2 in Arabidopsis thaliana
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
VAP27-2Vamp/synaptobrevin-associated protein 27-2; Encodes VAP33-like protein that interacts with cowpea mosaic virus protein 60K. Is a SNARE-like protein that may be involved in vesicular transport to or from the ER (386 aa)    
Predicted Functional Partners:
ARA7
Ras-related small GTP-binding family protein; Endosomal protein that may be involved in endocytosis. Involved in the trafficking of proteins from prevacuolar compartments (PVCs) to vacuoles. May activate the MON1-CCZ1 complex which acts as guanine nucleotide exchange factors (GEF) for Rab7 protein family, and serves as a link between Rab5 and Rab7 families in PVCs, and mediates PVC maturation. Involved in vacuolar transport of storage proteins with EREX as effector. Regulates membrane trafficking to protein storage vacuoles (PSVs); Belongs to the small GTPase superfamily. Rab family (200 aa)
     
  0.920
VAP27-1
Encodes VAP27 (for Vesicle-Associated Protein). VAP27 has high homology to the VAP33 family of SNARE-like proteins from animals. May be involved in vesicular transport to or from the ER. Located exclusively in limiting membrane of protein storage vacuoles. Binds SRC2 (256 aa)
         
0.914
DGL1
Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit family protein; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains; Belongs to the DDOST 48 kDa subunit family (437 aa)
     
    0.914
RABF2A
Ras-related protein RABF2a; Involved in the trafficking of soluble cargo proteins from the prevacuolar compartment to the central vacuole. Involved in vacuolar transport of storage proteins with EREX as effector. Regulates membrane trafficking to protein storage vacuoles (PSVs); Belongs to the small GTPase superfamily. Rab family (200 aa)
     
  0.911
PVA12
Vesicle-associated protein 1-2; Encodes a Plant VAMP-Associated protein that localizes to the ER and binds to the sitosterol-binding protein ORP3a. The WFDE motif in ORP3a appears to be important for this direct interaction. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family (239 aa)
         
0.909
AT5G16880
Target of Myb protein 1; Might contribute to the loading of the ESCRT machinery; Belongs to the TOM1 family (407 aa)
     
 
    0.907
AT1G06210
ENTH/VHS/GAT family protein; Binds ubiquitin in vitro. Might contribute to the loading of the ESCRT machinery (Probable); Belongs to the TOM1 family (383 aa)
     
 
    0.906
At2g29900
Presenilin-like protein At2g29900; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family (397 aa)
     
 
  0.904
At1g08700
Presenilin-like protein At1g08700; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family (453 aa)
     
 
  0.904
ARLA1D
ADP-ribosylation factor-like protein 8b; A member of ARF-like GTPase family. A thaliana has 21 members, in two subfamilies, ARF and ARF-like (ARL) GTPases (184 aa)
       
    0.900
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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