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BIP3 protein (Arabidopsis thaliana) - STRING interaction network
"BIP3" - Probable mediator of RNA polymerase II transcription subunit 37b in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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BIP3Probable mediator of RNA polymerase II transcription subunit 37b; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and t [...] (675 aa)    
Predicted Functional Partners:
CNX1
Calnexin homolog 1; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity) (530 aa)
     
 
  0.994
AT4G16660
Heat shock protein 70 (Hsp 70) family protein; Its function is described as ATP binding; Located in plasma membrane, chloroplast; Expressed in 24 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Heat shock protein 70, conserved site (InterPro-IPR018181), Heat shock protein Hsp70 (InterPro-IPR001023), Heat shock protein 70 (InterPro-IPR013126); BEST Arabidopsis thaliana protein match is- heat shock protein 70 (Hsp 70) family protein (TAIR-AT1G11660.1); Has 30201 Blast hits to 17322 proteins in 780 species- Archae - 12; Bacteria - 1396; Metazo [...] (867 aa)
   
 
0.990
AT5G07340
Calreticulin family protein; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity) (540 aa)
     
 
  0.987
SHD
Chaperone protein htpG family protein; Encodes an ortholog of GRP94, an ER-resident HSP90-like protein and is involved in regulation of meristem size and organization. Single and double mutant analyses suggest that SHD may be required for the correct folding and/or complex formation of CLV proteins. Lines carrying recessive mutations in this locus exhibits expanded shoot meristems, disorganized root meristems, and defective pollen tube elongation. Transcript is detected in all tissues examined and is not induced by heat. Endoplasmin supports the protein secretory pathway and has a rol [...] (823 aa)
     
 
  0.986
ATERDJ2A
DnaJ / Sec63 Brl domains-containing protein; Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane (687 aa)
     
 
  0.982
ATERDJ2B
DnaJ / Sec63 Brl domains-containing protein; Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane (661 aa)
     
 
  0.981
BZIP28
Basic-leucine zipper (bZIP) transcription factor family protein; Encodes bZIP28, a putative membrane-tethered transcriptional factor. Up-regulated in response to heat; a bZIP28 null mutant has a heat-sensitive phenotype. bZIP28 has a similar domain structure to the mammalian ATF6 protein involved in the unfolded protein response (UPR), and shares a bZIP domain, transmembrane domain, and a canonical S1P cleavage site. The bZIP28 seems to be glycosylated in vivo. bZIP28 does not appear to be transcriptionally up-regulated by UPR-inducing tunicamycin (TM) treatment. But, the expression l [...] (675 aa)
       
 
  0.978
BZIP60
Basic region/leucine zipper motif 60; AtbZIP60 consists of a bZIP DNA binding domain followed by a putative transmembrane domain. GFP fusions containing the first 260 amino acids (AtbZIP60deltaC) are nuclear-localized. AtbZIP60 is upregulated by the addition of tunicamycin (ER stress response inductor), DTT (inhibitor of disulfide bond formation) and azetin-2-carboxylate (proline analog perturbing protein structure). Upon ER stress the protein is proteolyzed and the soluble part is translocalized into the nucleus. AtbZIP60deltaC can activate the promoters of the ER chaperones BiP1, BiP [...] (295 aa)
     
 
  0.967
AT3G20920
Translocation protein-related; Its function is described as protein transporter activity; Involved in protein transport; Located in plasma membrane, membrane; Expressed in 25 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- Translocation protein Sec62 (InterPro-IPR004728); Has 251 Blast hits to 251 proteins in 119 species- Archae - 0; Bacteria - 0; Metazoa - 97; Fungi - 63; Plants - 45; Viruses - 0; Other Eukaryotes - 46 (source- NCBI BLink) (365 aa)
     
 
  0.964
AT2G34250
SecY protein transport family protein; Its function is described as P-P-bond-hydrolysis-driven protein transmembrane transporter activity; Involved in response to salt stress, protein secretion; Located in membrane; Expressed in 23 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- SecY protein (InterPro-IPR002208), Translocon Sec61/SecY, plug domain (InterPro-IPR019561); BEST Arabidopsis thaliana protein match is- SecY protein transport family protein (TAIR-AT1G29310.1); Has 35333 Blast hits to 34131 proteins in 2444 species- Archae - 798; Ba [...] (475 aa)
   
 
  0.955
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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