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PHYA protein (Arabidopsis thaliana) - STRING interaction network
"PHYA" - Phytochrome A in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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PHYAPhytochrome A; Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light- the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose- bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reduc [...] (1122 aa)    
Predicted Functional Partners:
PIF3
Transcription factor PIF3; Transcription factor acting positively in the phytochrome signaling pathway. Activates transcription by binding to the G box (5’-CACGTG-3’) (524 aa)
     
  0.999
CRY1
Cryptochrome 1; Photoreceptor that mediates primarily blue light inhibition of hypocotyl elongation and photoperiodic control of floral initiation, and regulates other light responses, including circadian rhythms, tropic growth, stomata opening, guard cell development, root development, bacterial and viral pathogen responses, abiotic stress responses, cell cycles, programmed cell death, apical dominance, fruit and ovule development, seed dormancy, and magnetoreception. Photoexcited cryptochromes interacts with signaling partner proteins to alter gene expression at both transcriptional [...] (681 aa)
     
 
  0.998
COP1
CONSTITUTIVE PHOTOMORPHOGENIC 1; E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repre [...] (675 aa)
       
 
  0.989
CRY2
Cryptochrome 2; Photoreceptor that mediates primarily blue light inhibition of hypocotyl elongation and photoperiodic control of floral initiation, and regulates other light responses, including circadian rhythms, tropic growth, stomata opening, guard cell development, root development, bacterial and viral pathogen responses, abiotic stress responses, cell cycles, programmed cell death, apical dominance, fruit and ovule development, seed dormancy, and magnetoreception. Photoexcited cryptochromes interacts with signaling partner proteins to alter gene expression at both transcriptional [...] (612 aa)
     
   
  0.978
HFR1
LONG HYPOCOTYL IN FAR-RED; Atypical bHLH transcription factor that regulates photomorphogenesis through modulation of phytochrome and cryptochrome signalings. Suppresses the transcriptional regulation activity of PIF4 by forming non-DNA-binding heterodimer (292 aa)
     
 
  0.977
SPA1
SUPPRESSOR OF PHYA-105 1; Controls normal photoperiodic flowering and regulates circadian rhythms. Required for suppression of photomorphogenesis in dark-grown seedlings and for normal elongation growth of adult plants. Integral component of the COP1/SPA E3 ubiquitin-protein ligase complex. Involved in HY5, HFR1, LAF1 and CO degradation (1029 aa)
       
 
  0.968
PKS1
Phytochrome kinase substrate 1; May be responsible for light-regulated cytoplasmic sequestration of phytochromes or may be a negative regulator of phytochrome B signaling. Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling. Acts positively in PHOT1 signaling. Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism. Involved in the control of leaf flattening and leaf positioning. Promotes negative root phototropism and negatively regulates root gravitropism. May act by controlling auxin homeostasis (439 aa)
       
 
  0.964
FHY3
Far-red elongated hypocotyls 3; Transcription activator that recognizes and binds to the DNA consensus sequence 5’-CACGCGC-3’. Activates the expression of FHY1 and FHL involved in light responses. When associated with PHYA, protects it from being recognized and degraded by the COP1/SPA complex. Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression (839 aa)
     
 
  0.964
PHOT1
Phototropin 1; Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Phosphorylates BLUS1, a kinase involved in stomatal opening. Required for blue light mediated mRNA destabilization. Mediates calcium spiking of extracellular origin in response to a low rate of blue light. Also mediates rapid membrane depolarization and growth inhibition in response to blue light. Necessary for root phototropism. Involved in hypocotyl phototropism under a low rate but not under a high rate of blue light. Contributes to the chloroplast accu [...] (996 aa)
     
   
  0.963
HY5
ELONGATED HYPOCOTYL 5; Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes (168 aa)
           
  0.959
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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