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SK18 protein (Arabidopsis thaliana) - STRING interaction network
"SK18" - SKP1-like 18 in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SK18SKP1-like 18; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F- box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F- box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity) (183 aa)    
Predicted Functional Partners:
AT3G42830
RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate (By similarity) (115 aa)
     
  0.995
CUL1
Cullin 1; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(A [...] (738 aa)
     
  0.990
RBX1
RING-box 1 (142 aa)
     
  0.972
UBC3
Ubiquitin-conjugating enzyme 3; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (150 aa)
       
  0.969
UBC2
Ubiquiting-conjugating enzyme 2; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (152 aa)
       
  0.969
UBC1
Ubiquitin carrier protein; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (152 aa)
       
  0.969
AT5G49200
Zinc finger CCCH domain-containing protein 62 (419 aa)
       
  0.964
AT5G40880
Zinc finger CCCH domain-containing protein 59 (472 aa)
       
  0.964
SDS
cyclin-SDS; Meiosis-specific cyclin. Required for normal homolog synapsis and recombination in early to mid-prophase 1. May regulate the timing of sister chromatid separation (578 aa)
       
  0.956
CKS2
CDK-subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (83 aa)
       
  0.954
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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