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SK18 protein (Arabidopsis thaliana) - STRING interaction network
"SK18" - SKP1-like protein 18 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SK18SKP1-like protein 18; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F- box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F- box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity); Belongs to the SKP1 family (183 aa)    
Predicted Functional Partners:
SKP2A
F-box/RNI-like superfamily protein; AtSKP2;1 is a homolog of human SKP2, the human F-box protein that recruits E2F1. Contains an F-box motif at the N-terminal region and a C-terminal Leu-rich repeat domain. Forms part of an E3-ubiquitin-ligase SCF (Skp1, cullin, F-box) complex and recruits phosphorylated AtE2Fc, a transcriptional factor that might play a role in cell division and during the transition from skotomorphogenesis to photomorphogenesis. AtSKP2;1 (At1g21410) and AtSKP2;2 (At1g77000) may be duplicated genes (360 aa)
       
  0.982
AT3G42830
RING/U-box superfamily protein; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate (By similarity); Belongs to the RING-box family (115 aa)
     
  0.979
EBF1
EIN3-binding F box protein 1; Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins. Confers insensitivity to ethylene (628 aa)
       
  0.968
FBP7
F-box protein 7; This gene is predicted to encode an F-box protein that is evolutionarily conserved between Arabidopsis and other eukaryotes including S.cerevisiae and humans. It may play a role in regulating translation under conditions of temperature stress. FBP7 transcript levels are increased at high and low temperatures (328 aa)
       
  0.957
UBC7
Ubiquitin-conjugating enzyme E2 7; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation (203 aa)
     
  0.946
UBC13
Ubiquitin-conjugating enzyme E2 13; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation; Belongs to the ubiquitin-conjugating enzyme family (166 aa)
     
  0.946
UBC22
Ubiquitin-conjugating enzyme E2 22; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins; Belongs to the ubiquitin-conjugating enzyme family (251 aa)
       
  0.935
UBC27
Ubiquitin-conjugating enzyme E2 27; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins; Belongs to the ubiquitin-conjugating enzyme family (203 aa)
     
  0.932
EBF2
EIN3-binding F box protein 2; Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins (623 aa)
       
  0.930
UPL4
E3 ubiquitin-protein ligase UPL4; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (1502 aa)
       
  0.930
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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