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NAT8 protein (Arabidopsis thaliana) - STRING interaction network
"NAT8" - Nucleobase-ascorbate transporter 8 in Arabidopsis thaliana
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NAT8Nucleobase-ascorbate transporter 8 (NAT8); Its function is described as transmembrane transporter activity; Involved in transport, transmembrane transport; Located in membrane; Expressed in 12 plant structures; Expressed during 7 growth stages; Contains the following InterPro domains- Xanthine/uracil/vitamin C permease (InterPro-IPR006043); BEST Arabidopsis thaliana protein match is- nucleobase-ascorbate transporter 7 (TAIR-AT1G60030.1); Has 9247 Blast hits to 9232 proteins in 1900 species- Archae - 67; Bacteria - 7567; Metazoa - 351; Fungi - 128; Plants - 453; Viruses - 1; Other Eukar [...] (539 aa)    
Predicted Functional Partners:
AZG2
Xanthine/uracil permease family protein; Encodes a homolog of the adenine-guanine-hypoxanthine transporter AzgA of Aspergillus nidulans. Function as a plant adenine-guanine transporter. Two closely related genes exist in Arabidopsis- AT3G10960 (Azg1) and AT5G50300 (Azg2) (530 aa)
 
   
  0.753
AT2G26230
Uricase / urate oxidase / nodulin 35, putative; Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin; Belongs to the uricase family (309 aa)
   
   
  0.742
AZG1
Adenine/guanine permease AZG1; Encodes a homolog of the adenine-guanine-hypoxanthine transporter AzgA of Aspergillus nidulans. Function as a plant adenine-guanine transporter. Two closely related genes exist in Arabidopsis- AT3G10960 (Azg1) and AT5G50300 (Azg2) (579 aa)
   
   
  0.690
PYD1
Dihydropyrimidine dehydrogenase (NADP(+)), chloroplastic; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate and the reduction of thymine to 5,6- dihydrothymine (DHT). Involved in the recycling of nitrogen from nucleobases to general nitrogen metabolism; Belongs to the dihydropyrimidine dehydrogenase family (426 aa)
   
   
  0.663
NCS1
Permease, cytosine/purines, uracil, thiamine, allantoin family protein; Nucleobase-proton symporter that facilitates the uptake of nucleobases in the cells. Can transport adenine, guanine and uracil. Contributes to uracil import into plastids for plastidic uracil salvage which is essential for plant growth and development (599 aa)
   
   
  0.643
PUP11
Probable purine permease 11; Member of a family of proteins related to PUP1, a purine transporter. May be involved in the transport of purine and purine derivatives such as cytokinins, across the plasma membrane (379 aa)
           
  0.618
UPS5
Ureide permease 5; Proton-coupled transporter that transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine, but not adenine. Mediates transport of uracil and 5-fluorouracil (a toxic uracil analog); Belongs to the plant ureide permease (TC 2.A.7.19) family (413 aa)
           
  0.612
AT4G38225
Glycerol kinase; Unknown protein; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Has 35333 Blast hits to 34131 proteins in 2444 species- Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source- NCBI BLink) (365 aa)
         
  0.610
CARA
Carbamoyl-phosphate synthase small chain, chloroplastic; Involved in arginine biosynthesis. Required for mesophyll development; Belongs to the CarA family (430 aa)
   
   
  0.587
MSS1
Major facilitator superfamily protein; Encodes a protein with high affinity, hexose-specific/H+ symporter activity. The activity of the transporter appears to be negatively regulated by phosphorylation. Importantly, microarray analysis, as well as the study of the expression of this gene in mutants involved in programmed cell death (PCD) demonstrated a tight correlation between this gene’s expression and PCD (526 aa)
           
  0.584
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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