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COAB protein (Arabidopsis thaliana) - STRING interaction network
"COAB" - Phosphopantothenate--cysteine ligase 1 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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COABPhosphopantothenate--cysteine ligase 1; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine (317 aa)    
Predicted Functional Partners:
ATHAL3B
Putative phosphopantothenoylcysteine decarboxylase; Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4’-phosphopantothenoylcysteine to 4’-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine (201 aa)
       
  0.992
PANK2
Pantothenate kinase 2; Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK1 (901 aa)
     
 
  0.989
HAL3A
HAL3-like protein A; Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4’-phosphopantothenoylcysteine to 4’-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine (209 aa)
       
  0.983
PANK1
Pantothenate kinase 1; Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK2 (383 aa)
     
 
  0.958
COAD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4’- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4’-phosphopantothenoylcysteine as a substrate (176 aa)
     
  0.941
DES1
Cysteine synthase A; Involved in maintaining Cys homeostasis through the desulfuration of L-cysteine. Modulates the generation of the signaling molecule sulfide in plant cytosol. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein (323 aa)
       
  0.820
CYSD2
Cysteine synthase D2; Acts as a cysteine synthase. The cysteine synthesis reaction is more efficient than the cyanoalanine synthase activity (323 aa)
       
  0.820
OASA1
Cysteine synthase; Acts as a major cysteine synthase, probably involved in maintaining organic sulfur level (322 aa)
       
  0.820
CYSC1
Cysteine synthase C1; Acts as a major beta-cyanoalanine synthase. The cyanoalanine synthesis reaction is more efficient than the cysteine synthase activity. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein. Probably involved in the detoxification of cyanide that arises from ethylene biosynthesis. Maintains a low level of cyanide for proper root hair development (368 aa)
       
  0.820
OASC
Cysteine synthase; Acts as a cysteine synthase. Plays a role in the sulfide detoxification in mitochondria (433 aa)
       
  0.820
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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