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COAB protein (Arabidopsis thaliana) - STRING interaction network
"COAB" - At1g12350 encodes phosphopantothenoylcysteine synthetase (phosphopantothenoylcysteine ligase). Its molecular function was shown to add cysteine forming in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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COABAt1g12350 encodes phosphopantothenoylcysteine synthetase (phosphopantothenoylcysteine ligase). Its molecular function was shown to add cysteine forming (R)-4-phospho-N-pantothenoylcysteine (PPC) (317 aa)    
Predicted Functional Partners:
PANK1
Pantothenate kinase 1; Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK2; Belongs to the type II pantothenate kinase family (383 aa)
     
 
  0.998
HAL3A
Phosphopantothenoylcysteine decarboxylase; Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4’-phosphopantothenoylcysteine to 4’-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine; Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily (209 aa)
       
  0.984
ATCOAE
AT2G27490 encodes dephospho-CoA kinase. The molecular function was shown to phosphorylate the ribosyl moiety forming CoA; Belongs to the CoaE family (232 aa)
   
 
  0.975
PANK2
Pantothenate kinase 2; Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK1 (901 aa)
     
 
  0.964
ATHAL3B
Probable phosphopantothenoylcysteine decarboxylase; Encodes a protein similar to yeast HAL3, which regulates the cell cycle and tolerance to salt stress through inhibition of the PPZ1 type-1 protein phosphatase. AtHAL3b mRNA levels are induced by salt stress. HAL3B presumably encodes for phosphopantothenoylcysteine decarboxylase being involved in Coenzyme A biosynthesis as indicated by functional complementation of a double mutant hal3 aaBb; Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily (201 aa)
       
  0.958
COAD
4-phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4’- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4’-phosphopantothenoylcysteine as a substrate (176 aa)
     
 
  0.954
AT4G35360
Uncharacterised conserved protein (UCP030210); Contains the following InterPro domains- Domain of unknown function DUF89 (InterPro-IPR002791), Uncharacterised conserved protein UCP030210 (InterPro-IPR016949); BEST Arabidopsis thaliana protein match is- Uncharacterised conserved protein (UCP030210) (TAIR-AT2G17340.1); Has 30201 Blast hits to 17322 proteins in 780 species- Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source- NCBI BLink) (367 aa)
     
   
  0.933
AT2G17320
Uncharacterised conserved protein (UCP030210); Contains the following InterPro domains- Domain of unknown function DUF89 (InterPro-IPR002791), Uncharacterised conserved protein UCP030210 (InterPro-IPR016949); BEST Arabidopsis thaliana protein match is- Uncharacterised conserved protein (UCP030210) (TAIR-AT2G17340.1); Has 35333 Blast hits to 34131 proteins in 2444 species- Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source- NCBI BLink) (361 aa)
     
   
  0.930
PANC
Pantoate--beta-alanine ligase; Encodes a pantothenate synthetase that appears to be located in the cytosol. This protein is expected to play a role in pantothenate (vitamin B5) biosynthesis. Analysis of the catalytic properties of this enzyme indicate that it might be able to synthesize adequate amounts of pantothenate even in the presence of low levels of pantoate (310 aa)
   
 
  0.913
MRH10_18
Glutathione gamma-glutamylcysteinyltransferase 1; Phytochelatin synthase gene confers tolerance to cadmium ions. Catalyzes phytochelatin (PC) synthesis from glutathione (GSH) in the presence of Cd2+, Zn2+, Cu2+ and Fe3+, but not by Co2+ or Ni2+ (485 aa)
           
  0.840
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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