SCRM2 protein (Arabidopsis thaliana) - STRING interaction network
"SCRM2" - SCREAM 2 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
SCRM2SCREAM 2; Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA (450 aa)    
Predicted Functional Partners:
SPEECHLESS; Transcription factor. Together with FMA and MUTE, regulates the stomata formation. Required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions (364 aa)
MUTE; Transcription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata (202 aa)
EPIDERMAL PATTERNING FACTOR 1; Controls stomatal patterning. Regulates asymmetric cell division during guard cell differentiation. Mediates stomatal development inhibition. Not cleaved by the protease CRSP (AC Q9LNU1) (PubMed-25043023). MEPF1- mobile signal controlling stomatal development in a non-cell-autonomous manner (PubMed-22241782). Uses ERL1 as major receptor (PubMed-22241782). May act by competing with somatogen (AC Q9SV72) for the same receptor, TMM (AC Q9SSD1) (PubMed-22027592) (104 aa)
TOO MANY MOUTHS; Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC). Modulates probably the activity of the ligand- receptor pairs EPF2-ERECTA and EPF1-ERL1 via heterodimerization (PubMed-22241782) (496 aa)
EPIDERMAL PATTERNING FACTOR 2; Controls stomatal patterning. Regulates the number of cells that enter, and remain in, the stomatal lineage by inhibiting protodermal cells from adopting the meristemoid mother cell (MMC) fate in a non-cell-autonomous manner. Mediates stomatal development inhibition. MEPF2- mobile signal controlling stomatal development in a non-cell-autonomous manner (PubMed-22241782). Uses ERECTA as major receptor (PubMed-22241782). Inactivated by cleavage by CRSP (AC Q9LNU1) (PubMed-25043023). May act by competing with somatogen (AC Q9SV72) for the same receptor, TMM ( [...] (120 aa)
ERECTA-like 1; Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ER and ERL2. Redundantly involved with ER in procambial development regulation. Forms a functional ligand-receptor pair with EPF1 (AC Q8S8I4) (PubMed-22241782) (966 aa)
YODA; Functions in a MAP kinase cascade that acts as a molecular switch to regulate the first cell fate decisions in the zygote and the early embryo. Promotes elongation of the zygote and development of its basal daughter cell into the extra-embryonic suspensor. In stomatal development, acts downstream of the LRR receptor TMM, but upstream of the MKK4/MKK5-MPK3/MPK6 module to regulate stomatal cell fate before the guard mother cell (GMC) is specified. Plays a central role in both guard cell identity and pattern formation. This MAPK cascade also functions downstream of the ER receptor i [...] (883 aa)
STOMAGEN; Stomagen- Positively regulates stomatal density and patterning. May act by competing with either EPF1 (AC Q8S8I4) or EPF2 (AC Q8LC53) for the same receptor, TMM (AC Q9SSD1). Not cleaved by the protease CRSP (AC Q9LNU1) (PubMed-25043023) (102 aa)
FAMA; Transcription activator. Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (414 aa)
Protein TIFY 6A; Repressor of jasmonate responses (310 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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