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NUDT12 protein (Arabidopsis thaliana) - STRING interaction network
"NUDT12" - Nudix hydrolase 12 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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Score
NUDT12Nudix hydrolase 12; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (203 aa)    
Predicted Functional Partners:
PDXH
Pyridoxin (pyrodoxamine) 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP). Involved in the PLP salvage pathway. Has a higher preference for PNP over PMP. May also catalyze the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (530 aa)
     
 
  0.927
DCP1
Decapping 1; As a component of the decapping complex, involved in the degradation of mRNAs. Essential for postembryonic development (367 aa)
       
 
  0.900
NUDX1
Nudix hydrolase 1; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Its substrate specificity is unclear. In vitro, it can use NTP, dNTP, 8-oxo-GTP, 8-oxo-dGTP, dGTP, dATP, dTTP or dihydroneopterin triphosphate (DHNTP) as substrate. Has some NADH pyrophosphatase activity in vitro; however, such activity may not be relevant in vivo due to the high concentration of manganese used during the experiments. Plays an important role in protection against oxidative DNA and RNA damage by removing oxidatively damaged form of guanine (147 aa)
         
  0.885
NUDX19
Nudix hydrolase 19; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Has a high affinity for NADPH compared with that for NADH (438 aa)
       
 
  0.872
NUDX27
Nudix hydrolase 27; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use diadenosine 5’,5’’’-P(1)P(5) pentaphosphate (Ap(5)A) as substrates (227 aa)
     
   
  0.869
NUDT3
Nudix hydrolase 3; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (772 aa)
           
  0.869
NUDX25
Nudix hydrolase 25; Mediates the hydrolysis of diadenosine 5’,5’’-P(1)P(4) tetraphosphate (Ap(4)A), a signaling molecule involved in regulation of DNA replication and repair (175 aa)
           
  0.867
NUDT11
Nudix hydrolase 11; Coenzyme A diphosphatase which mediates the cleavage of CoA into 3’,5’-ADP from CoA and 4’-phosphopantetheine. Can use malonyl-CoA, hexanoyl-CoA, lauroyl-CoA, myristoyl-CoA and palmitoyl-CoA as substrates, but not isobutyryl-CoA or propionyl- CoA (222 aa)
           
  0.864
NUDT2
Nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. In vitro, it can use both NADH and ADP- ribose as substrates; however the relevance of such substrates in vivo is unclear (278 aa)
           
  0.861
NUDT8
Nudix hydrolase 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (369 aa)
           
  0.861
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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