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DOT5 protein (Arabidopsis thaliana) - STRING interaction network
"DOT5" - Encodes a putative zinc finger protein (C2H2 family, type IIIA, subclass A1d) that has a WIP domain. Seedlings with mutations in DOT5 have a misaligned venation defect in their leaves and cotyledons. Additional developmental abnormalities, such as elongated petioles and aberrant phyllotaxy suggest that DOT5 is required for normal shoot and root development in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DOT5Encodes a putative zinc finger protein (C2H2 family, type IIIA, subclass A1d) that has a WIP domain. Seedlings with mutations in DOT5 have a misaligned venation defect in their leaves and cotyledons. Additional developmental abnormalities, such as elongated petioles and aberrant phyllotaxy suggest that DOT5 is required for normal shoot and root development (302 aa)    
Predicted Functional Partners:
AT2G20050
Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein; Protein serine/threonine phosphatases;protein kinases;catalytics;cAMP-dependent protein kinase regulators;ATP binding;protein serine/threonine phosphatases; Its function is described as cAMP-dependent protein kinase regulator activity, protein kinase activity, protein serine/threonine phosphatase activity, catalytic activity, ATP binding; Involved in protein amino acid phosphorylation, protein amino acid dephosphorylation, N-terminal protein myristoylation, regulation of protein amino acid phosphoryl [...] (1094 aa)
     
 
  0.871
NAC023
NAC domain containing protein 23 (NAC023); Contains the following InterPro domains- No apical meristem (NAM) protein (InterPro-IPR003441); BEST Arabidopsis thaliana protein match is- NAC domain containing protein 24 (TAIR-AT1G60350.1); Has 1617 Blast hits to 1595 proteins in 68 species- Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1617; Viruses - 0; Other Eukaryotes - 0 (source- NCBI BLink) (347 aa)
           
  0.710
NF-YB7
Nuclear transcription factor Y subunit B-7; Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters (215 aa)
     
 
  0.666
NAC077
NAC domain containing protein 77 (NAC077); Its function is described as DNA binding; Involved in multicellular organismal development, regulation of transcription; Located in cellular_component unknown; Expressed in shoot, flower, leaf; Expressed during petal differentiation and expansion stage, LP.08 eight leaves visible; Contains the following InterPro domains- No apical meristem (NAM) protein (InterPro-IPR003441); BEST Arabidopsis thaliana protein match is- NAC domain containing protein 52 (TAIR-AT3G10490.2); Has 1807 Blast hits to 1807 proteins in 277 species- Archae - 0; Bacteria [...] (395 aa)
           
  0.663
LBD10
LOB domain-containing protein 10 (LBD10); Involved in biological_process unknown; Expressed in 8 plant structures; Expressed during L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; Contains the following InterPro domains- Lateral organ boundaries, LOB (InterPro-IPR004883), Asymmetric leaves, AS2/LOB (InterPro-IPR017414); BEST Arabidopsis thaliana protein match is- ASYMMETRIC LEAVES 2-like 1 (TAIR-AT5G66870.1); Has 1085 Blast hits to 1079 proteins in 38 species- Archae - 0; Bacteria - 8; Metazoa - 18; Fungi - 1; Plants - 1055; Viru [...] (311 aa)
           
  0.643
FIE
Encodes a protein similar to the transcriptional regular of the animal Polycomb group and is involved in regulation of establishment of anterior-posterior polar axis in the endosperm and repression of flowering during vegetative phase. Mutation leads endosperm to develop in the absence of fertilization and flowers to form in seedlings and non-reproductive organs. Also exhibits maternal effect gametophytic lethal phenotype, which is suppressed by hypomethylation. Forms part of a large protein complex that can include VRN2 (VERNALIZATION 2), VIN3 (VERNALIZATION INSENSITIVE 3) and polyco [...] (369 aa)
       
 
  0.633
MYB84
Transcription factor RAX3; "Putative homolog of the Blind gene in tomato. Together with RAX1 and RAX3 belong to the class R2R3 MYB genes; encoded by the Myb-like transcription factor MYB84, regulates axillary meristem formation. " (310 aa)
       
 
  0.579
TSA2
Tryptophan synthase alpha chain, chloroplastic; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate. Required for tryptophan biosynthesis. Contributes to the tryptophan-independent indole biosynthesis, and possibly to auxin production; Belongs to the TrpA family (312 aa)
           
  0.557
At5g53660
Growth-regulating factor 7; Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (365 aa)
           
  0.550
RR18
Two-component response regulator ARR18; Transcriptional activator that binds specifically to the DNA sequence 5’-[AG]GATT-3’. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity) (618 aa)
       
 
  0.549
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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