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FDM4 protein (Arabidopsis thaliana) - STRING interaction network
"FDM4" - XH/XS domain-containing protein in Arabidopsis thaliana
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FDM4XH/XS domain-containing protein; Acts in association with FDM3 and FDM5 for RNA-directed DNA methylation (RdDM) (736 aa)    
Predicted Functional Partners:
SGS3
XS domain-containing protein / XS zinc finger domain-containing protein-related; Required for posttranscriptional gene silencing and natural virus resistance.SGS3 is a member of an ’unknown’ protein family. Members of this family have predicted coiled coiled domains suggesting oligomerization and a potential zinc finger domain. Involved in the production of trans-acting siRNAs, through direct or indirect stabilization of cleavage fragments of the primary ta-siRNA transcript. Acts before RDR6 in this pathway (625 aa)
     
 
  0.836
FDM2
XH/XS domain-containing protein; Forms a complex with IDN2 and FDM1/IDNL1 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (635 aa)
     
 
0.637
FDM3
XH/XS domain-containing protein; Acts in association with FDM4 and FDM5 for RNA-directed DNA methylation (RdDM) (638 aa)
     
 
0.635
FDM5
XH/XS domain-containing protein; Acts in association with FDM3 and FDM4 for RNA-directed DNA methylation (RdDM) (634 aa)
         
0.624
IDL2
Similar to Inflorescence deficient in abscission (IDA). Involved in floral organ abscission (95 aa)
           
  0.624
FDM1
XH/XS domain-containing protein; Forms a complex with IDN2 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway. Required for de novo DNA methylation and 24 nucleotide small interfering RNA (siRNA) accumulation. Binds unmethylated but not methylated DNAs through its coiled-coil domain. May bind double- stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain. However, according to, FMD1 does not bind dsRNAs (634 aa)
         
0.621
IDN2
XH/XS domain-containing protein; Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway and downstream of small interfering RNA (siRNA) formation. Required for de novo DNA methylation, siRNA accumulation and siRNA-mediated maintenance methylation. Required for several post-transcriptional gene silencing pathways. Binds double-stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain. Binds long non- coding RNA (lncRNA) in an AGO4-dependent manner and associates with DRM2, r [...] (647 aa)
         
0.599
P40
40S ribosomal protein Sa-1; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits; Belongs to the universal ribosomal protein uS2 family (298 aa)
           
  0.590
IDL1
Inflorescence deficient in abscission (IDA)-like 1; Involved in an ethylene-independent separation step of floral abscission. May act with RLK5 and HSL2 as ligand-receptor pairs (86 aa)
           
  0.571
DMS3
Protein DEFECTIVE IN MERISTEM SILENCING 3; Component of the RNA-directed DNA methylation (RdDM) machinery, probably by facilitating an RNAi-mediated epigenetic modification involving secondary siRNAs and spreading of DNA methylation, thus leading to gene silencing. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. Required for de novo DNA methylation (420 aa)
           
  0.568
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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