• Version:
  • 11.0 (preview - - version 10.5 still available here)
WHY1 protein (Arabidopsis thaliana) - STRING interaction network
"WHY1" - Single-stranded DNA-binding protein WHY1, chloroplastic in Arabidopsis thaliana
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
WHY1Single-stranded DNA-binding protein WHY1, chloroplastic; Single-stranded DNA-binding protein that functions in both chloroplasts and nucleus. In chloroplasts, maintains plastid genome stability by preventing break-induced and short homology- dependent illegitimate recombinations. In nucleus, modulates telomere length homeostasis by inhibiting the action of the telomerase at the extreme termini of chromosomes. Is recruited to a distal element upstream of the kinesin KP1 to mediate the transcriptional repression of KP1. Is required for full salicylic acid-dependent plant disease resistan [...] (263 aa)    
Predicted Functional Partners:
MAR binding filament-like protein 1; Binds DNA. Interacts with chromatin via matrix attachment regions (MARs). Likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (By similarity) (726 aa)
Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic; Involved in plastid gene expression. Required in the nucleus for the initiation of photomorphogenesis mediated by phytochromes (PHYs) (e.g. PHYA and PHYB) by mediating PHYs localization to photobodies, especially in response to red and far-red light, and implicating phytochrome nuclear bodies as sites of proteolysis for PHYs and PIFs proteins (e.g. PIF1 and PIF3). Acts downstream of PHYs and upstream of DET1 (527 aa)
Pumilio homolog 24; Encodes a member of the Arabidopsis Pumilio (APUM) proteins containing PUF domain (eight repeats of approximately 36 amino acids each). PUF proteins regulate both mRNA stability and translation through sequence-specific binding to the 3’ UTR of target mRNA transcripts (641 aa)
Protein PLASTID REDOX INSENSITIVE 2, chloroplastic; Involved in redox-mediated retrograde signaling to synchronize the expression of photosynthetic genes from both the nuclear and plastidic genomes, especially in excess light conditions. Required for full expression of genes transcribed by the plastid-encoded RNA polymerase (PEP). Essential for embryo development (179 aa)
Pentatricopeptide repeat-containing protein At2g31400, chloroplastic; Encodes a a chloroplast-localized pentatricopeptide-repeat protein involved in regulation of nuclear gene expression (918 aa)
Pentatricopeptide repeat-containing protein At3g06430, chloroplastic; Embryo defective 2750 (EMB2750); Involved in pollen tube development, embryo development ending in seed dormancy; Located in chloroplast; Contains the following InterPro domains- Pentatricopeptide repeat (InterPro-IPR002885); BEST Arabidopsis thaliana protein match is- Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR-AT3G53170.1); Has 31867 Blast hits to 12007 proteins in 283 species- Archae - 3; Bacteria - 31; Metazoa - 288; Fungi - 376; Plants - 30037; Viruses - 0; Other Eukaryotes - 1132 (source- NCBI [...] (486 aa)
Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic; Required for the splicing of group IIA introns in chloroplasts, by regulating the intron folding. Forms splicing particles with RNA. May also be involved in chloroplast protein translation (720 aa)
Ribonuclease III domain-containing protein RNC1, chloroplastic; Binds specific group II introns in chloroplasts and facilitates their splicing. Acts on both subgroup IIA and subgroup IIB introns. The substrates of the subgroup II also require the CRM domain proteins CAF1 or CAF2. Binds both single-stranded and double-stranded RNA non-specifically, but lacks endonuclease activity. Required for plastid ribosome biogenesis (537 aa)
Fructokinase-like 2, chloroplastic; Required for proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription. Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression; Belongs to the carbohydrate kinase PfkB family (616 aa)
Thioredoxin-like fold domain-containing protein MRL7, chloroplastic; Plays an essential role in early steps of chloroplast development. Involved in the regulation of plastid gene expression. May positively regulate plastid-encoded RNA polymerase (PEP) activity through binding to FSD3 and CITRX/TRXZ. Involved in redox-mediated regulation of chloroplast development. Possesses disulfide reductase activity in vitro. Required for the proper function of the plastid transcriptional machinery and protein accumulation in thylakoid membranes. May function as molecular chaperone to ensure proper [...] (331 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (8%) [HD]